ID   A0A1U7IMJ8_9CYAN        Unreviewed;       464 AA.
AC   A0A1U7IMJ8;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Cytosine-specific methyltransferase {ECO:0000256|RuleBase:RU000417};
DE            EC=2.1.1.37 {ECO:0000256|RuleBase:RU000417};
GN   ORFNames=NIES2119_10435 {ECO:0000313|EMBL:OKH38438.1};
OS   Phormidium ambiguum IAM M-71.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC   Oscillatoriales; Oscillatoriaceae; Phormidium.
OX   NCBI_TaxID=454136 {ECO:0000313|EMBL:OKH38438.1, ECO:0000313|Proteomes:UP000185860};
RN   [1] {ECO:0000313|EMBL:OKH38438.1, ECO:0000313|Proteomes:UP000185860}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAM M-71 {ECO:0000313|EMBL:OKH38438.1,
RC   ECO:0000313|Proteomes:UP000185860};
RA   Zhu T., Hou S., Lu X., Hess W.R.;
RT   "Draft Genome Sequences of Nine Cyanobacterial Strains from Diverse
RT   Habitats.";
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC         methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC         Evidence={ECO:0000256|RuleBase:RU000417};
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKH38438.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MRCE01000008; OKH38438.1; -; Genomic_DNA.
DR   RefSeq; WP_073593401.1; NZ_MRCE01000008.1.
DR   AlphaFoldDB; A0A1U7IMJ8; -.
DR   STRING; 454136.NIES2119_10435; -.
DR   REBASE; 190687; M.PamM71ORF10435P.
DR   OrthoDB; 9813719at2; -.
DR   Proteomes; UP000185860; Unassembled WGS sequence.
DR   GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR018117; C5_DNA_meth_AS.
DR   InterPro; IPR001525; C5_MeTfrase.
DR   InterPro; IPR031303; C5_meth_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; TIGR00675; dcm; 1.
DR   PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR   Pfam; PF00145; DNA_methylase; 1.
DR   PRINTS; PR00105; C5METTRFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00094; C5_MTASE_1; 1.
DR   PROSITE; PS00095; C5_MTASE_2; 1.
DR   PROSITE; PS51679; SAM_MT_C5; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW   ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000185860};
KW   Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01016};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU01016}.
FT   ACT_SITE        106
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ   SEQUENCE   464 AA;  53330 MW;  6BCB072903A8E847 CRC64;
     MKNSNTLYLP QQLELFKPIH IFAAHRLTNY KFTFVDLFAG IGGFRIPLEQ LGGKCLGYSE
     IDKAAIKVYE QNFVGYCNLE EKNLGDIRQI SKLPFAVDII VGGVPCQSWS VAGNLQGFKD
     PRGQLWFDTI RVIKENKPKS FIFENVRTLM SDVHRSSLDL LLTEFENLGY KVKVSLLNSY
     DFGVPQNRER TFIVGINNAI EKASKFKFPE PLKEQAKLIN ILDTNKDFQL DVKPKINPSI
     LFGDKVPYSR NRFQKADEFN DFFVFCDTRD GHTTIHSWDI IKTTKREKQI CLTILRNRRK
     KKYGEKDGNP LSFDVLAELI PNLEIKEVEQ LISKNILRYV VNLGYEFVNS KNSAGINGLY
     RIFLPSSDAI PTLTATGTND FIATVSLKHC EDPVTYKKLF LREIYRKKRY RPISALDAKR
     LQGFPEWFQM HENENIAKFQ FGNAVSVPVV YHLAKSLLDL LVIN
//