ID A0A1U7J4T8_9CYAN Unreviewed; 843 AA.
AC A0A1U7J4T8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=NIES30_12005 {ECO:0000313|EMBL:OKH47705.1};
OS Phormidium tenue NIES-30.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales; Oscillatoriaceae; Phormidium.
OX NCBI_TaxID=549789 {ECO:0000313|EMBL:OKH47705.1, ECO:0000313|Proteomes:UP000185557};
RN [1] {ECO:0000313|EMBL:OKH47705.1, ECO:0000313|Proteomes:UP000185557}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-30 {ECO:0000313|EMBL:OKH47705.1,
RC ECO:0000313|Proteomes:UP000185557};
RA Zhu T., Hou S., Lu X., Hess W.R.;
RT "Draft Genome Sequences of Nine Cyanobacterial Strains from Diverse
RT Habitats.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH47705.1}.
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DR EMBL; MRCG01000008; OKH47705.1; -; Genomic_DNA.
DR RefSeq; WP_073608664.1; NZ_MRCG01000008.1.
DR AlphaFoldDB; A0A1U7J4T8; -.
DR STRING; 549789.NIES30_12005; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000185557; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR NCBIfam; TIGR01063; gyrA; 1.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 4.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000185557};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 15..474
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT COILED 446..515
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 843 AA; 93164 MW; 20A7CB6265019187 CRC64;
MADQLDIIAG QIVPTSLHTE VQRSYLEYAM SVIVGRALPD VRDGLKPVHR RILYAMHELG
LTPDRPYRKC ARVVGDVLGK YHPHGDQAVY EALVRMVQTF SSRYPLLDGH GNFGSVDNDP
PAAMRYTETR LSPISNEAML TDISEALVDF SDNFDSSQQE PVVLPTQLPN LLLNGSSGIA
VGMATNIPPH NMGEVVDGLV AMIDRPAITD DELFRLIPGP DFPTGGEIIG TEGILDAYRT
GRGSIPIRGI CQFEEVHPGR GRQRRNAIIV TELPYQVNKA GWIEKIAQLV NAGRLEGIAD
IRDESDRDGM RVVIELKRDT PAQRVLQDLY RTTPLQTNFG VIMLALDDGQ PRQMPLRDVM
QAFLDFRETT LTRHYQHQLE KTEAKLHITE GLLTALNNLD AIIDILRNAA DGTTAKQIFQ
QRFDLSERQS DAILAMPLRK LTGMERQGLE NDFAELSQRR DDLNRLLSDR KELLKAMKKE
LKVLKKKFND PRRTRIQTEA ERAEESQQVE EIIAETVEEA TVVEFTQKGY VRRFSQKAYQ
RRQARLEVDT SAKLHEVDDD PVVQVEAALT THELLTLTRD GRAFTVDVGA VPTNPRQGKG
APLVQLLPGS VPSAADAIVA RLVLRDDLLE HDLILVTRRG KIKRAPLKEF TNLTGRGLTA
IKVKDGDELA YVTLAEPGDD LVLGTTGGRL LRFPIDDDNL QVMGRAAQGP QGIRMGKQET
LTGCVAVQSS KDCLLLVSAA GYAKRLPVEG LRVAKRGDIG TQSFQFSLKT DSLMALLPAV
PKEAVTVFTS AERTAVIPIG SVPRQGRTGE SDRIVKPNKG ETITQVIRVT TLDPDASNGA
ASD
//
