ID A0A1U7J8U0_9CYAN Unreviewed; 894 AA.
AC A0A1U7J8U0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=NIES30_03995 {ECO:0000313|EMBL:OKH49884.1};
OS Phormidium tenue NIES-30.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales; Oscillatoriaceae; Phormidium.
OX NCBI_TaxID=549789 {ECO:0000313|EMBL:OKH49884.1, ECO:0000313|Proteomes:UP000185557};
RN [1] {ECO:0000313|EMBL:OKH49884.1, ECO:0000313|Proteomes:UP000185557}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-30 {ECO:0000313|EMBL:OKH49884.1,
RC ECO:0000313|Proteomes:UP000185557};
RA Zhu T., Hou S., Lu X., Hess W.R.;
RT "Draft Genome Sequences of Nine Cyanobacterial Strains from Diverse
RT Habitats.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKH49884.1}.
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DR EMBL; MRCG01000002; OKH49884.1; -; Genomic_DNA.
DR RefSeq; WP_073607124.1; NZ_MRCG01000002.1.
DR AlphaFoldDB; A0A1U7J8U0; -.
DR STRING; 549789.NIES30_03995; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000185557; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000185557}.
FT DOMAIN 743..759
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 669..676
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 894 AA; 99250 MW; BBC365B38C9C16AD CRC64;
MPGSSPSADS QPPIPERLAK HTVRYADHHS VNWDDLTPMM RHYVEMKEQY PHALVLYRVG
DFFETFFQDA IAIARELELV LTSKEAGKAI GRVPLAGIPH HALDRYCMLL VERGYAIAIC
DQVEDPAVAQ GLVKREVTRV ITPGTVIEEG MLSASQNNFL ASVVVAGHHW GLAHADVSTG
EFLTTQGEDL DQLCQELLRL QPAEVLFPVD APNLGAMLRP GDQSDQLPDC LPRQFCYTLR
PQGPYSQSEA RQRLLQRFRL RSLEGLGCDH LPLAVRAAGG LLHYVEETQK TVQAPLQPLC
TYTLSAYLVI DHQTRRNLEI TQTARDGTYN GSLLWALDRT VTAMGGRTLR RWLLQPLLDV
KGIQQRQSTI VELLQDGNLR QMLQHKLKQI YDLERLAGRA GSGTANARDL VALADSFLRL
PDLAALAEQA QSPYLKALQY VPPELEQLGQ TLRSHLVETP PLYLTEGHLI RDGVNAQLDD
LRQQAVDDQK WIAELEPAER KRTGISTLKV GFNKAFGYYI SISRARADQA PDDYIRKQTL
TNEERYITPE LKERETRVFN IESEINALEY EIFNQLREKV GEQVELIRKV AAAVAAADVL
CGLAEVAIFQ GYCCPEMDES RAIAVTEGRH PVVEQLLPAG FFVPNSNYMG TIPSDRDAAH
AQDLIILTGP NASGKSCYLR QVGLIQLMAQ MGSFVPAKTA RLGVCDRIFT RVGAVDDLAS
GQSTFMVEMN ETANILNHAT PRSLVLLDEI GRGTATFDGL SIAWAVAEHL AVEIEARTIF
ATHYHELNEL AALIPNVANY QVTVKEMPDQ IIFLHQVQPG GADKSYGIEA GRLAGLPTSV
IQRARDVMRE IERNSTIAVG LRGEVSKLSK PRRRAKDVTG TYDPSEQLDL FGKS
//
