ID   A0A1U7M4E1_TISCR        Unreviewed;       756 AA.
AC   A0A1U7M4E1;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=von Willebrand factor type A domain protein {ECO:0000313|EMBL:OLS02182.1};
GN   ORFNames=TICRE_20010 {ECO:0000313|EMBL:OLS02182.1};
OS   Tissierella creatinophila DSM 6911.
OC   Bacteria; Bacillota; Tissierellia; Tissierellales; Tissierellaceae;
OC   Tissierella.
OX   NCBI_TaxID=1123403 {ECO:0000313|EMBL:OLS02182.1, ECO:0000313|Proteomes:UP000186112};
RN   [1] {ECO:0000313|EMBL:OLS02182.1, ECO:0000313|Proteomes:UP000186112}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6911 {ECO:0000313|EMBL:OLS02182.1,
RC   ECO:0000313|Proteomes:UP000186112};
RA   Poehlein A., Daniel R.;
RT   "Genome sequence of Tissierella creatinophila DSM 6911.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OLS02182.1}.
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DR   EMBL; LTDM01000043; OLS02182.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1U7M4E1; -.
DR   OrthoDB; 1656124at2; -.
DR   Proteomes; UP000186112; Unassembled WGS sequence.
DR   CDD; cd00198; vWFA; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR   PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR   Pfam; PF05345; He_PIG; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000186112}.
FT   DOMAIN          215..424
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          37..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..57
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..129
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   756 AA;  81992 MW;  43506B3095182463 CRC64;
     MRNLFKSLVP ILLIISMIFS LGIEGISVDN PITENTIKQG ETLTDPPKEE VKENPKEETQ
     IPQQPQIPKE PDKEPQNPQD SESTPEPNLP EIPTKPENPK EEVKEDPKEP DIPKEEPKED
     PKEEPETPEE PKEEIVEEEE EIIEDELAEN IPPIAGEPEI VLPDFYYQEM MRPSLLTSGL
     TDTIEVDKTA SRVPGCRTYE VKLDITGIPQ KAPVDVVLVI DRSGSMNETA SSNPTRSRLY
     YAKQAAINFA GKVLGPNGIA GSRVSVVSFS GPSTTTGNGA QNQASTDLGL TSNLSQVTSI
     INNITAVGGT NTEAGFLQGK SVITNSGNPS SNKVLIMFTD GIPTASNGNR YGPDDPTSHN
     NHTRAAYTAG QSIWPLADVF TIGLLQNMNA SVKALAIDTL TKAQNKGFYN APSAQDLDQI
     FTLISQQLGY SATNAVVVDK LGDNFELVLG SLPAGASYNS NTREITWTPG TIVEHSQLKY
     TIQAKSSFQG GLANTNEYAK LTYKDINGNQ GITKIFPKPS VNVPAPLKVS LTDANIKLTT
     LITLGSGTDP NGENYMSPIT GGDGNGTYTY EWRVVGNSTV ISTNKNPTVN LSTSPTQYEL
     TVTDSNGCKA KAIMTVEVKG AITITKQVLN PKGLNIDPNQ EFDIFLNGPN GVQYVVSLKN
     GESKTVENLS LGNYIISEIV PMNYKNKSIT NANISLNLTN LQSQSIVTNE LDNGGWFHDD
     DIRENKFKVG IVSVPLRQVI IPKELEEVKD GLEKND
//