ID A0A1U7M5H4_TISCR Unreviewed; 408 AA.
AC A0A1U7M5H4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN Name=hhaIM_3 {ECO:0000313|EMBL:OLS02574.1};
GN ORFNames=TICRE_13750 {ECO:0000313|EMBL:OLS02574.1};
OS Tissierella creatinophila DSM 6911.
OC Bacteria; Bacillota; Tissierellia; Tissierellales; Tissierellaceae;
OC Tissierella.
OX NCBI_TaxID=1123403 {ECO:0000313|EMBL:OLS02574.1, ECO:0000313|Proteomes:UP000186112};
RN [1] {ECO:0000313|EMBL:OLS02574.1, ECO:0000313|Proteomes:UP000186112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6911 {ECO:0000313|EMBL:OLS02574.1,
RC ECO:0000313|Proteomes:UP000186112};
RA Poehlein A., Daniel R.;
RT "Genome sequence of Tissierella creatinophila DSM 6911.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLS02574.1}.
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DR EMBL; LTDM01000022; OLS02574.1; -; Genomic_DNA.
DR RefSeq; WP_075726447.1; NZ_LTDM01000022.1.
DR AlphaFoldDB; A0A1U7M5H4; -.
DR REBASE; 193719; M1.Tcr6911ORF13750P.
DR OrthoDB; 9813719at2; -.
DR Proteomes; UP000186112; Unassembled WGS sequence.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd00315; Cyt_C5_DNA_methylase; 1.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR031303; C5_meth_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00675; dcm; 1.
DR PANTHER; PTHR46098; TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR46098:SF1; TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00095; C5_MTASE_2; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000186112};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT ACT_SITE 73
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 408 AA; 45468 MW; 144158CF4B4BE900 CRC64;
MEFIDLCAGI GGFRLGLELA GHKCVGFCEI DKYAVKSYKA MHDTEGEWYR DDITKLKSEE
IPYADIWTFG FPCQDISVAG KQKGLRGERS GIYFSIIDLI KGKEEKDKPT YLLIENVKNL
LSINGGFDFT TVLSELDQAG YDAMWQVLNS KDFGVPQNRE RVFIIANLRS RGRREILPIG
GENSAAIKQI IDGRQGDRVL DPKGISCTLT GNGGGWGGKT GLYFIDQSTT KTKITENSRC
ITSRYTAGIV NRTAMNSGVL EARAVITPER KEKRQNGRRM KDLDEPMFTL TGQDRHGVAI
KEATKKGFAE AEIGDSINVS FPNSKTRRGR VGKKVAQTLD TKCMQATLSD NYRIRRLTPK
ECFRLQGFPD EMFEKARKVN SDSQLYKQAG NAVTVNVAYA IAMTLGKE
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