ID A0A1U7M6T0_TISCR Unreviewed; 627 AA.
AC A0A1U7M6T0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=PTS system fructose-specific EIIABC component {ECO:0000313|EMBL:OLS02985.1};
GN Name=fruA {ECO:0000313|EMBL:OLS02985.1};
GN ORFNames=TICRE_10420 {ECO:0000313|EMBL:OLS02985.1};
OS Tissierella creatinophila DSM 6911.
OC Bacteria; Bacillota; Tissierellia; Tissierellales; Tissierellaceae;
OC Tissierella.
OX NCBI_TaxID=1123403 {ECO:0000313|EMBL:OLS02985.1, ECO:0000313|Proteomes:UP000186112};
RN [1] {ECO:0000313|EMBL:OLS02985.1, ECO:0000313|Proteomes:UP000186112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6911 {ECO:0000313|EMBL:OLS02985.1,
RC ECO:0000313|Proteomes:UP000186112};
RA Poehlein A., Daniel R.;
RT "Genome sequence of Tissierella creatinophila DSM 6911.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLS02985.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LTDM01000013; OLS02985.1; -; Genomic_DNA.
DR RefSeq; WP_075725861.1; NZ_LTDM01000013.1.
DR AlphaFoldDB; A0A1U7M6T0; -.
DR OrthoDB; 9782569at2; -.
DR Proteomes; UP000186112; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005351; F:carbohydrate:proton symporter activity; IEA:InterPro.
DR GO; GO:0022877; F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR CDD; cd00211; PTS_IIA_fru; 1.
DR CDD; cd05569; PTS_IIB_fructose; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR InterPro; IPR002178; PTS_EIIA_type-2_dom.
DR InterPro; IPR036095; PTS_EIIB-like_sf.
DR InterPro; IPR013011; PTS_EIIB_2.
DR InterPro; IPR003501; PTS_EIIB_2/3.
DR InterPro; IPR003352; PTS_EIIC.
DR InterPro; IPR013014; PTS_EIIC_2.
DR InterPro; IPR004715; PTS_IIA_fruc.
DR InterPro; IPR003353; PTS_IIB_fruc.
DR InterPro; IPR006327; PTS_IIC_fruc.
DR NCBIfam; TIGR00829; FRU; 1.
DR NCBIfam; TIGR00848; fruA; 1.
DR NCBIfam; TIGR01427; PTS_IIC_fructo; 1.
DR PANTHER; PTHR30505; FRUCTOSE-LIKE PERMEASE; 1.
DR PANTHER; PTHR30505:SF28; PTS SYSTEM 2-O-ALPHA-MANNOSYL-D-GLYCERATE-SPECIFIC EIIABC COMPONENT; 1.
DR Pfam; PF00359; PTS_EIIA_2; 1.
DR Pfam; PF02378; PTS_EIIC; 1.
DR Pfam; PF02302; PTS_IIB; 1.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
DR SUPFAM; SSF52794; PTS system IIB component-like; 1.
DR PROSITE; PS51094; PTS_EIIA_TYPE_2; 1.
DR PROSITE; PS00372; PTS_EIIA_TYPE_2_HIS; 1.
DR PROSITE; PS51099; PTS_EIIB_TYPE_2; 1.
DR PROSITE; PS51104; PTS_EIIC_TYPE_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Reference proteome {ECO:0000313|Proteomes:UP000186112};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 595..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..149
FT /note="PTS EIIA type-2"
FT /evidence="ECO:0000259|PROSITE:PS51094"
FT DOMAIN 171..266
FT /note="PTS EIIB type-2"
FT /evidence="ECO:0000259|PROSITE:PS51099"
FT DOMAIN 289..626
FT /note="PTS EIIC type-2"
FT /evidence="ECO:0000259|PROSITE:PS51104"
SQ SEQUENCE 627 AA; 66545 MW; F08966699E5AE02A CRC64;
MKITNLIKKD TIILNLESVK KEDILEELIE ELYTANRLND REEFKKEILK RESEGTTGIG
DGIAIPHAKT KAVKIPSIAF GRSKTGVDFD SLDGEPTNLF FMIAASEGAD NDHLETLSKL
ATFLMDKDFS KNLLKANSKE EIIEIIDKKE MEEENKLAKK DTSQDVKREK ILAVTACPTG
IAHTYMAADA LKQKAEEMGV DIKVETNGST GVKNELTQED IREAKAIIVS ADTKVYMDRF
DGKKVIQTPV SEAIKNPQGL IKRALEGEGN IYKGKGETSS TSKTGGKNIY TNLMNGVSNM
LPFVVGGGIL IALSFLFDFN NAGGGDYGSG NSIAAFFNTL GGTAFSFMLP ILAGYIAFSI
GDRPALAPGF VGGALAANGN AGFLGALFAG FLAGYIVVGL RKLFDKLPNS LEGIKPVLLF
PLFGILIVGF VMNFIIVPPV EALNTGMNNF LNTLGGSNKV ILGLLLGGMM AVDMGGPVNK
AAYVFGVASV AEGNGHIMAA VMAGGMVPPL GIALATTLFK DKFTLAERDA GKTNYVMGLS
FITEGAIPFA AADPKSVIPS IIVGSAIAGG LSELFGASSP APHGGIFVFP VVSNWLLYFA
SILIGSVVTA ILLKILKKDI QIQKVNS
//
