ID A0A1U7ME60_9FIRM Unreviewed; 740 AA.
AC A0A1U7ME60;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364053};
DE EC=5.6.2.4 {ECO:0000256|RuleBase:RU364053};
GN Name=pcrA {ECO:0000313|EMBL:OLS55747.1};
GN ORFNames=SPSPH_30760 {ECO:0000313|EMBL:OLS55747.1};
OS Sporomusa sphaeroides DSM 2875.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Sporomusaceae;
OC Sporomusa.
OX NCBI_TaxID=1337886 {ECO:0000313|EMBL:OLS55747.1, ECO:0000313|Proteomes:UP000186950};
RN [1] {ECO:0000313|EMBL:OLS55747.1, ECO:0000313|Proteomes:UP000186950}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2875 {ECO:0000313|EMBL:OLS55747.1,
RC ECO:0000313|Proteomes:UP000186950};
RA Poehlein A., Daniel R.;
RT "Genome sequence of Sporomusa sphaeroides DSM 2875.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618,
CC ECO:0000256|RuleBase:RU364053};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922, ECO:0000256|RuleBase:RU364053}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLS55747.1}.
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DR EMBL; LSLJ01000003; OLS55747.1; -; Genomic_DNA.
DR RefSeq; WP_075756704.1; NZ_LSLJ01000003.1.
DR AlphaFoldDB; A0A1U7ME60; -.
DR STRING; 1337886.SPSPH_30760; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000186950; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR01073; pcrA; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA-binding {ECO:0000256|RuleBase:RU364053};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000186950}.
FT DOMAIN 6..285
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 286..561
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 740 AA; 82945 MW; 5858320D72029F24 CRC64;
MNNIFDRLNP AQQEAVAHVN GPLLIMAGAG SGKTKVLTSR IANLLAQGVA PYNILAITFT
NKAAAEMKAR VAGIVGLVAK DIWLSTFHAF CAKFLRMEIE NLGGYTRNFV IYDAGDSQSL
IKTCLKELNL DEKQFTPGGV QSTISNAKNA LQDVREFTSQ ADNFYNLRVA EVYKLYQSKL
KVHNALDFDD LLMLSVELLE YNATVREKYQ QKFHYILIDE YQDTNRAQYL LARRLAAKHR
NICVVGDVDQ SIYAWRGADI QNILDFESDY PDAKVIKLEQ NYRSTQTILD AANAVIENNC
NRKPKSLWTD NQAGDTITHY LAMDERDEAR YITDNIVKLN TVYRTPYKDI AILYRTNAQS
RTIEEGLRNA AIPYTMVGGL RFYDRKEIKD IMAYIKVLFN PADAVSLLRI INVPRRGIGN
TTIGRLEEYA AGQGVPLFDA VSNPDLVPGL TKRAKHQLEG LAELIFNLMS CQNTLPVPEL
VDKVMRDSGY LAELEADSDP QAMSRIENLK ELVSDAKKFA ETEAENTLEE FLSHVSLLTD
LDNNEFSDDK VTLMTLHSAK GLEFPVVFLA GLEEGIFPHV RTLMDEREIE EERRLCYVGI
TRAERKLYIS NARQRMIYGN TVCYSPSRFL DEIPPELMER YAPGRPAYLS SMPGSRPVAA
ASLPKAAVKP ELTILKSPVQ NPAKPQNLEW KAGEKVYHAK WGTGTVVAVS GSGDNMQLSI
AFPNEGIKKL LAQLAPISRV
//