ID A0A1U7NMU4_9FIRM Unreviewed; 654 AA.
AC A0A1U7NMU4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA-directed DNA polymerase family A palm domain-containing protein {ECO:0000259|SMART:SM00482};
GN ORFNames=BO225_05415 {ECO:0000313|EMBL:OLU46610.1};
OS Dubosiella newyorkensis.
OC Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC Erysipelotrichaceae; Dubosiella.
OX NCBI_TaxID=1862672 {ECO:0000313|EMBL:OLU46610.1, ECO:0000313|Proteomes:UP000186705};
RN [1] {ECO:0000313|EMBL:OLU46610.1, ECO:0000313|Proteomes:UP000186705}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NYU-BL-A4 {ECO:0000313|EMBL:OLU46610.1,
RC ECO:0000313|Proteomes:UP000186705};
RA Cox L.M., Sohn J., Tyrrell K.L., Citron D.M., Lawson P.A., Patel N.B.,
RA Iizumi T., Perez-Perez G.I., Goldstein E.J., Blaser M.J.;
RT "Description of two novel members of the family Erysipelotrichaceae:
RT Ileibacterium lipovorans gen. nov., sp. nov. and Dubosiella newyorkensis,
RT gen. nov., sp. nov.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLU46610.1}.
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DR EMBL; MPKA01000062; OLU46610.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1U7NMU4; -.
DR STRING; 1862672.BO225_05415; -.
DR OrthoDB; 9764911at2; -.
DR Proteomes; UP000186705; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR012337; RNaseH-like_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000186705}.
FT DOMAIN 378..617
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 654 AA; 74375 MW; E07184475DFC7653 CRC64;
MKTRSPRVLH IDLETYSPID LGKSSVYNYC EDAGFQILLL AFAYNDDPVQ VIEMPTRKTM
PAKVLRDILD PEVMKVAHNA SFERICLSHA FGDGKNHNYL DPKAWYCTMI HACELGLPAS
LKHCAEAIGC ELAKDSAGTL LINYFSKPCK PTKANGGRTR NMPEDDPEKW GRFVFYNKRD
VEVEQEIYNK LRRYPMPEEE WMRYCIDQRI NDTGVRLEMT MIKNLTEKYP LMVKEMKEEC
EKITGGINLN SIIQLKEWIY QETGMQIESL NKPTIKELLK GELPEDVRRV LELRLESGSS
SIKKYIAMTK CVSDDGRVRG CFRFFGGRTG RWAGRLVQFQ NMPSKLAFYD FDPARQCVLN
NDFDMLTLLY GSITEAAKTL IRTVIVPEEG HKLIVADYSA IEARVIAWLA DEGWRMKAFA
DGKDIYCASA SQMFGVPVEK HGVNSHLRKQ GKVAELALGY QGGIGALIAF GADKMGLNET
EMKEIVRKWR GASPHICKLW RSIESGFKRC LNGEAVNLRH GIRFIRRPGY VFIQLPSGRC
MAYWMPTLKD DKISYAKHTG TKMSRVDTFG GKLTENIVQA IARDCLAVAL ERVTKRTDFR
IIAHVHDEII CEVPADRAEE SLQILEDLMA EPIDWAPGLI LTADGFVSDY YKKD
//
