ID A0A1U7Q281_MESAU Unreviewed; 483 AA.
AC A0A1U7Q281;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=macrophage receptor MARCO {ECO:0000313|RefSeq:NP_001268535.1};
GN Name=Marco {ECO:0000313|RefSeq:NP_001268535.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:NP_001268535.1};
RN [1] {ECO:0000313|RefSeq:NP_001268535.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10224290; DOI=10.1084/jem.189.9.1497;
RA Palecanda A., Paulauskis J., Al-Mutairi E., Imrich A., Qin G., Suzuki H.,
RA Kodama T., Tryggvason K., Koziel H., Kobzik L.;
RT "Role of the scavenger receptor MARCO in alveolar macrophage binding of
RT unopsonized environmental particles.";
RL J. Exp. Med. 189:1497-1506(1999).
RN [2] {ECO:0000313|RefSeq:NP_001268535.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR RefSeq; NP_001268535.1; NM_001281606.1.
DR AlphaFoldDB; A0A1U7Q281; -.
DR SMR; A0A1U7Q281; -.
DR GeneID; 101834359; -.
DR KEGG; maua:101834359; -.
DR CTD; 8685; -.
DR OrthoDB; 5266999at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1101; MACROPHAGE RECEPTOR MARCO; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF00530; SRCR; 1.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 1.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR PROSITE; PS00420; SRCR_1; 1.
DR PROSITE; PS50287; SRCR_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:NP_001268535.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 45..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 389..483
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT REGION 146..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 114..141
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 198..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 452..462
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 483 AA; 49622 MW; C38F18C46505FB1E CRC64;
MGNKKALKEE AFLGSAEEGA DFDQAMFPVM ETFEINDPMP KKRNWGSFCT AVMAIHLILL
TAGTTLLTLK VLSLQKWILE KYLDNETLAA EDRSFFSLQL ASPETHLVPR TPGLQALQVQ
LTQVRTSQEQ LLQQVDNLTR NPELFRIKGE RGSPGIPGLQ GPPGIKGEAG LQGPMGAPRE
PGATGAPGPQ GEKGSKGDKG LIGPKGEHGT KGDKGDLGLP GSKGDMGMKG VTGVMGPPGA
QGNKGDPGKP GLPGLAGSPG VKGDQGQPGL QGVPGTPGAA GPSGAKGEPG HPGPPGPTGP
QGISGSPGAA GLKGSKGDTG IQGQKGTKGE SGVPGLAGRK GDTGNPGLAG PKGEPGRPGL
KGDPGMKGSS GQQGQKGEKG EKGQSFKEVR IVGGTNRGRA EIFYNNAWGT ICDDNWDNND
ATVFCRMLGY SSGKGFTFGG GSGNIWLDDV NCQGTEDSLW NCRKNNWGSH NCNHNEDAGV
ECR
//
