ID A0A1U7Q282_MESAU Unreviewed; 485 AA.
AC A0A1U7Q282;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 22-FEB-2023, entry version 19.
DE SubName: Full=NGFI-A-binding protein 1 {ECO:0000313|RefSeq:NP_001268536.1};
GN Name=Nab1 {ECO:0000313|RefSeq:NP_001268536.1};
GN Synonyms=TA16 {ECO:0000313|RefSeq:NP_001268536.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:NP_001268536.1};
RN [1] {ECO:0000313|RefSeq:NP_001268536.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9259324; DOI=10.1210/me.11.9.1342;
RA Fan W., Ma J.X., Cheng L., Norris J.S.;
RT "Molecular cloning of TA16, a transcriptional repressor that may mediate
RT glucocorticoid-induced growth arrest of leiomyosarcoma cells.";
RL Mol. Endocrinol. 11:1342-1352(1997).
RN [2] {ECO:0000313|RefSeq:NP_001268536.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2017) to UniProtKB.
CC -!- SUBUNIT: Homomultimers may associate with EGR1 bound to DNA.
CC {ECO:0000256|ARBA:ARBA00011364}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NAB family. {ECO:0000256|ARBA:ARBA00008864}.
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DR RefSeq; NP_001268536.1; NM_001281607.1.
DR AlphaFoldDB; A0A1U7Q282; -.
DR SMR; A0A1U7Q282; -.
DR GeneID; 101827193; -.
DR KEGG; maua:101827193; -.
DR CTD; 4664; -.
DR OrthoDB; 4181992at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.20.120.2010; NAB conserved domain 2; 1.
DR InterPro; IPR006986; Nab1_C.
DR InterPro; IPR006989; NAB_co-repressor_dom.
DR InterPro; IPR039040; NAB_fam.
DR InterPro; IPR006988; Nab_N.
DR InterPro; IPR038398; NCD2_sf.
DR PANTHER; PTHR12623; NGFI-A BINDING PROTEIN; 1.
DR PANTHER; PTHR12623:SF9; NGFI-A-BINDING PROTEIN 1; 1.
DR Pfam; PF04902; Nab1; 1.
DR Pfam; PF04904; NCD1; 1.
DR Pfam; PF04905; NCD2; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 6..83
FT /note="Nab N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04904"
FT DOMAIN 190..317
FT /note="NAB co-repressor"
FT /evidence="ECO:0000259|Pfam:PF04905"
FT DOMAIN 321..484
FT /note="Nab1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04902"
FT REGION 160..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 54062 MW; AD8EFC04D1460F62 CRC64;
MATALPRTLG ELQLYRILQK ANLLSYFGAF IQQGGDDVQQ LCEAGEEEFL EIMALVGMAS
KPLHVRRLQK ALRDWVTNPG LFNQPLTSLP VSSIPIYKLP KGSPTWLGIS CNSYERNSSA
REPHLKIPKC AATTCVQSLG QGKSEVGSLA VQSVSESRLW QGHHATESEH SLSPADVGSP
ASPKESSEAL DAAAALSVAE CVERMASTLP KSDLNEVKEL LKNNKKLAKM IGHIFEMSDE
DPHKEEEIRK YSAIYGRFDS KRKDGKHLTL HELTVNEAAA QLCVKDNALL TRRDELFALA
RQVSREVTYK YTYRTTRLKC GERDELSPKR IKVEDGFPDF QEPVQTLFQQ ARAKSEELAA
LSSQQTEKGM AKQMELLCAQ ASYERLQQER RLTAGLYRQS SGEHSPDGLP SDGSDGQGER
PLNLRMPNVQ NRQPHHFVAD GELSRLYSSE AKSHSSENLG ILKDYPHSAF TLEKKVIKTE
PEDSR
//
