ID A0A1U7Q2D2_MESAU Unreviewed; 327 AA.
AC A0A1U7Q2D2;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Interleukin-12 subunit beta {ECO:0000256|ARBA:ARBA00013416, ECO:0000256|RuleBase:RU281113};
DE Short=IL-12B {ECO:0000256|RuleBase:RU281113};
DE AltName: Full=Cytotoxic lymphocyte maturation factor 40 kDa subunit {ECO:0000256|ARBA:ARBA00032299, ECO:0000256|RuleBase:RU281113};
DE AltName: Full=IL-12 subunit p40 {ECO:0000256|ARBA:ARBA00029655, ECO:0000256|RuleBase:RU281113};
DE Flags: Precursor;
GN Name=Il12b {ECO:0000313|RefSeq:NP_001268618.1};
GN Synonyms=IL-12B {ECO:0000313|RefSeq:NP_001268618.1}, IL-12p40
GN {ECO:0000313|RefSeq:NP_001268618.1}, IL12B
GN {ECO:0000256|RuleBase:RU281113};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:NP_001268618.1};
RN [1] {ECO:0000313|RefSeq:NP_001268618.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9573100;
RA Melby P.C., Tryon V.V., Chandrasekar B., Freeman G.L.;
RT "Cloning of Syrian hamster (Mesocricetus auratus) cytokine cDNAs and
RT analysis of cytokine mRNA expression in experimental visceral
RT leishmaniasis.";
RL Infect. Immun. 66:2135-2142(1998).
RN [2] {ECO:0000313|RefSeq:NP_001268618.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14522013; DOI=10.1016/S0161-5890(03)00165-2;
RA Maruyama K., Takigawa Y., Akiyama Y., Hojo T., Nara-Ashizawa N.,
RA Cheng J.Y., Watanabe M., Yamaguchi K.;
RT "Structure and characterization of hamster IL-12 p35 and p40.";
RL Mol. Immunol. 40:319-326(2003).
RN [3] {ECO:0000313|RefSeq:NP_001268618.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2017) to UniProtKB.
CC -!- FUNCTION: Associates with IL23A to form the IL-23 interleukin, a
CC heterodimeric cytokine which functions in innate and adaptive immunity.
CC IL-23 may constitute with IL-17 an acute response to infection in
CC peripheral tissues. IL-23 binds to a heterodimeric receptor complex
CC composed of IL12RB1 and IL23R, activates the Jak-Stat signaling
CC cascade, stimulates memory rather than naive T-cells and promotes
CC production of pro-inflammatory cytokines. IL-23 induces autoimmune
CC inflammation and thus may be responsible for autoimmune inflammatory
CC diseases and may be important for tumorigenesis.
CC {ECO:0000256|ARBA:ARBA00033720}.
CC -!- FUNCTION: Cytokine that can act as a growth factor for activated T and
CC NK cells, enhance the lytic activity of NK/lymphokine-activated killer
CC cells, and stimulate the production of IFN-gamma by resting PBMC.
CC {ECO:0000256|ARBA:ARBA00002947, ECO:0000256|RuleBase:RU281113}.
CC -!- SUBUNIT: Heterodimer with IL12A; disulfide-linked. The heterodimer is
CC known as interleukin IL-12. {ECO:0000256|RuleBase:RU281113}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU281113}.
CC -!- SIMILARITY: Belongs to the IL-12B family.
CC {ECO:0000256|ARBA:ARBA00006261, ECO:0000256|RuleBase:RU281113}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; NP_001268618.1; NM_001281689.1.
DR AlphaFoldDB; A0A1U7Q2D2; -.
DR SMR; A0A1U7Q2D2; -.
DR GeneID; 101843678; -.
DR KEGG; maua:101843678; -.
DR CTD; 3593; -.
DR OrthoDB; 4006511at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR015528; IL-12_beta.
DR InterPro; IPR019482; IL-12_beta_cen-dom.
DR PANTHER; PTHR48397:SF1; INTERLEUKIN-12 SUBUNIT BETA; 1.
DR PANTHER; PTHR48397; INTERLEUKIN-12 SUBUNIT BETA-RELATED; 1.
DR Pfam; PF16681; Ig_5; 1.
DR Pfam; PF10420; IL12p40_C; 1.
DR PIRSF; PIRSF038007; IL_12_beta; 1.
DR PRINTS; PR01928; INTRLEUKN12B.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01354; HEMATOPO_REC_L_F3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU281113};
KW Glycoprotein {ECO:0000256|RuleBase:RU281113};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU281113};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Secreted {ECO:0000256|RuleBase:RU281113};
KW Signal {ECO:0000256|RuleBase:RU281113, ECO:0000313|RefSeq:NP_001268618.1}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU281113,
FT ECO:0000313|RefSeq:NP_001268618.1"
FT CHAIN 23..327
FT /note="Interleukin-12 subunit beta"
FT /evidence="ECO:0000256|RuleBase:RU281113"
FT /id="PRO_5010398451"
FT CHAIN 23..327
FT /note="Interleukin-12 subunit beta"
FT /evidence="ECO:0000313|RefSeq:NP_001268618.1"
FT /id="PRO_5009993580"
FT DOMAIN 19..90
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 238..327
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 327 AA; 37212 MW; 91E8CB910353C0D4 CRC64;
MCHQKLTISW FAVVLLASPL MAIWELEKDV YVVEVDWSPD AAGERVVLTC DTSEEDDIIW
TSDKNSEAVG SGKTLTIQVK EFSNAGQYTC HKGGKTLSHS RLLLHKKENG IWSTDILKDQ
KDPKNKTFLK CEAANYSGRF TCWWLTAIST DLKFNVKSSS SSSDSRAVTC GAASLSAEKV
TVDRKDYQKY SVACQEDITC PTAEETLPIG LVMEAQHKYK YENYSTGFFI RDIIKPDPPK
NLQLKPLRGS QMELSWEYPD SWSTPHSYFS LKFHVQVHRK RERKDESQFV DKTSATIRCS
KGAEVRVRAQ DHYYNSSWSR WVSVPCS
//
