ID A0A1U7Q4B5_MESAU Unreviewed; 129 AA.
AC A0A1U7Q4B5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=C-X-C motif chemokine {ECO:0000256|RuleBase:RU361149};
GN Name=LOC101835923 {ECO:0000313|RefSeq:XP_005068145.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005068145.1};
RN [1] {ECO:0000313|RefSeq:XP_005068145.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU361149}.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000256|ARBA:ARBA00010665, ECO:0000256|RuleBase:RU361149}.
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DR RefSeq; XP_005068145.1; XM_005068088.3.
DR AlphaFoldDB; A0A1U7Q4B5; -.
DR STRING; 10036.ENSMAUP00000022279; -.
DR GeneID; 101835923; -.
DR KEGG; maua:101835923; -.
DR eggNOG; ENOG502S7MM; Eukaryota.
DR OrthoDB; 4170999at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0008009; F:chemokine activity; IEA:Ensembl.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IEA:Ensembl.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0001776; P:leukocyte homeostasis; IEA:Ensembl.
DR GO; GO:0042119; P:neutrophil activation; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR GO; GO:0032642; P:regulation of chemokine production; IEA:Ensembl.
DR GO; GO:0070951; P:regulation of neutrophil mediated killing of gram-negative bacterium; IEA:Ensembl.
DR CDD; cd00273; Chemokine_CXC; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR001089; Chemokine_CXC.
DR InterPro; IPR018048; Chemokine_CXC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015:SF196; C-X-C MOTIF CHEMOKINE 6; 1.
DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00436; INTERLEUKIN8.
DR PRINTS; PR00437; SMALLCYTKCXC.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE 3: Inferred from homology;
KW Chemotaxis {ECO:0000256|RuleBase:RU361149};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU361149};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Secreted {ECO:0000256|RuleBase:RU361149};
KW Signal {ECO:0000256|RuleBase:RU361149}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|RuleBase:RU361149"
FT CHAIN 36..129
FT /note="C-X-C motif chemokine"
FT /evidence="ECO:0000256|RuleBase:RU361149"
FT /id="PRO_5010397770"
FT DOMAIN 47..107
FT /note="Chemokine interleukin-8-like"
FT /evidence="ECO:0000259|SMART:SM00199"
SQ SEQUENCE 129 AA; 13779 MW; 051B3213B9E42D39 CRC64;
MSPVPCCSAR ILGGSRLLFV RLAFLLLLTL PQHLAEGGPA AAAVATELRC VCLSVSPRIN
PKMIANLEVI AAGPQCPRVE VIAKLKNQKE VCLDPEAPLM KKIIQKILDS ANKKTKRNAL
ALETSPSGQ
//
