ID A0A1U7Q5I1_MESAU Unreviewed; 366 AA.
AC A0A1U7Q5I1;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Chromobox protein homolog 8 isoform X1 {ECO:0000313|RefSeq:XP_005069898.1};
GN Name=Cbx8 {ECO:0000313|RefSeq:XP_005069898.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005069898.1};
RN [1] {ECO:0000313|RefSeq:XP_005069898.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005069898.1; XM_005069841.3.
DR AlphaFoldDB; A0A1U7Q5I1; -.
DR STRING; 10036.ENSMAUP00000020476; -.
DR GeneID; 101824156; -.
DR KEGG; maua:101824156; -.
DR CTD; 57332; -.
DR eggNOG; KOG2748; Eukaryota.
DR OrthoDB; 75895at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0000792; C:heterochromatin; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0035102; C:PRC1 complex; IEA:Ensembl.
DR GO; GO:0035064; F:methylated histone binding; IEA:Ensembl.
DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0097027; F:ubiquitin-protein transferase activator activity; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd18627; CD_polycomb_like; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR033773; CBX7_C.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR PANTHER; PTHR46389:SF1; CHROMOBOX PROTEIN HOMOLOG 8; 1.
DR PANTHER; PTHR46389; POLYCOMB GROUP PROTEIN PC; 1.
DR Pfam; PF17218; CBX7_C; 1.
DR Pfam; PF00385; Chromo; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 11..69
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 101..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 366 AA; 40285 MW; 24BB8E9C53F4F169 CRC64;
MELSAVGERV FAAEALLKRR IRKGRMEYLV KWKGWSQKYS TWEPEENILD ARLLAAFEER
EREMELYGPK KRGPKPKTFL LKAQAKAKAK TYEFRSDSAR GIRIPYPGRS PQDLASTSRA
REGLRNTGLS PPGSSTSACR ADSPRDHRDR DRDRERGAGG RVDDKPSSPG DSSKKRGPKP
RKELLDPSQR PLGEPSDGLG EYLKGRKLED TSSGTGKFPV GHSVIQLARR QDSDLVQYGV
TSPSSAEASG KLAVDTFPAR VIKHRAAFLE AKGQGTLDPG GPRVRHSSGT PGSVGSLYRD
MGAQGGRPSL IARIPVARIL GDPEEESWSP SLTNLEKVVV TDVTSNFLTV TIKESNTDQG
FFKEKR
//
