ID A0A1U7Q5M4_MESAU Unreviewed; 520 AA.
AC A0A1U7Q5M4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=ADP-ribosylation factor GTPase-activating protein 2 {ECO:0000256|ARBA:ARBA00039244};
DE AltName: Full=Zinc finger protein 289 {ECO:0000256|ARBA:ARBA00043100};
GN Name=Arfgap2 {ECO:0000313|RefSeq:XP_005064980.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005064980.1};
RN [1] {ECO:0000313|RefSeq:XP_005064980.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004255}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004255}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004255}.
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DR RefSeq; XP_005064980.1; XM_005064923.3.
DR AlphaFoldDB; A0A1U7Q5M4; -.
DR STRING; 10036.ENSMAUP00000007572; -.
DR GeneID; 101841672; -.
DR CTD; 84364; -.
DR OrthoDB; 389572at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd09029; ArfGap_ArfGap2; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR PANTHER; PTHR45686; ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED; 1.
DR PANTHER; PTHR45686:SF10; ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}; Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 11..117
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 160..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 270..304
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 161..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..423
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 520 AA; 56707 MW; 69F4B4F9A8C5E232 CRC64;
MAAEPSKTEI QTLFKRLRSV PTNKACFDCG AKSPSWASIT YGVFLCIDCS GVHRSLGVHL
SFVRSTELDS NWSWLQLRCM QVGGNANATA FFRQHGCMAN DANTKYNSRA AQMYREKIRQ
LGSAALARHG TDLWIDNMSN APSHSPEKKD SDFFTEHTQA PVWDTADTET SGTQQPALSS
ESSIPAQPEH GPNTDLLGTS PQASLELKSS IIGKKKPAAA KKGLGAKKGL GAQKVSNQSF
TEIERQAQVA EKLREQQAAD AKKQAEESMV ASMRLAYQEL QIDRKKEEKK LQNLEGKKRE
QAERLGMGLV SRSSISHSVL SEMQVIEQET PLSAKSSRSQ LDLFDDVGTF ASGPPKYKDN
PFSLGETFGS RWDSDAAWGM DRVEEKEPEV TISSIRPISE RTTSRREVES RSSGPESSEA
REKFAGAKAI SSDMFFGREV DSEYEARSRL QQLSGSSAIS SSDLFGDMDG AHGGGTVSLG
NVLPTADIAQ FKQGVKSVAG KMAVLANGVM NSLQDRYGSY
//
