ID A0A1U7Q9D5_MESAU Unreviewed; 584 AA.
AC A0A1U7Q9D5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Protein CBFA2T1 isoform X2 {ECO:0000313|RefSeq:XP_005066885.1};
GN Name=Runx1t1 {ECO:0000313|RefSeq:XP_005066885.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005066885.1};
RN [1] {ECO:0000313|RefSeq:XP_005066885.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CBFA2T family.
CC {ECO:0000256|ARBA:ARBA00011004}.
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DR RefSeq; XP_005066885.1; XM_005066828.3.
DR AlphaFoldDB; A0A1U7Q9D5; -.
DR GeneID; 101827990; -.
DR KEGG; maua:101827990; -.
DR CTD; 862; -.
DR OrthoDB; 5314634at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 6.10.250.230; -; 1.
DR Gene3D; 1.20.120.1110; TAFH/NHR1 domain; 1.
DR InterPro; IPR013290; CBFA2T1.
DR InterPro; IPR013289; CBFA2T1/2/3.
DR InterPro; IPR014896; NHR2.
DR InterPro; IPR037249; TAFH/NHR1_dom_sf.
DR InterPro; IPR003894; TAFH_NHR1.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR10379; MTG8 ETO EIGHT TWENTY ONE PROTEIN; 1.
DR PANTHER; PTHR10379:SF5; PROTEIN CBFA2T1; 1.
DR Pfam; PF08788; NHR2; 1.
DR Pfam; PF07531; TAFH; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR PRINTS; PR01875; ETOFAMILY.
DR PRINTS; PR01876; MTG8PROTEIN.
DR SMART; SM00549; TAFH; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR SUPFAM; SSF158553; TAFH domain-like; 1.
DR PROSITE; PS51119; TAFH; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT DOMAIN 100..195
FT /note="TAFH"
FT /evidence="ECO:0000259|PROSITE:PS51119"
FT DOMAIN 495..531
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
FT REGION 1..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 434..476
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 10..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 584 AA; 64984 MW; 48B06A403F3B1B77 CRC64;
MVGLSGPVQY RTEKHSTMPD SPVDVKTQSR LTPPAMPPPP TTQGAPRTSS FTPTTLTNGT
SHSPTALNGA PSPPNGFSNG PSSSSSSSLA NQQLPPACGA RQLSKLKRFL TTLQQFGNDI
SPEIGERVRT LVLGLVNSTL TIEEFHSKLQ EATNFPLRPF VIPFLKANLP LLQRELLHCA
RLAKQNPAQY LAQHEQLLLD ASTTSPVDSS ELLLDVNENG KRRTPDRTKE NGFDREPLHS
EHPSKRPCTI SPGQRYSPNN GLSYQPNGLP HPTPPPPQHY RLDDMAIAHH YRDSYRHPSH
RDLRDRTRPM GLHGTRQEEM IDHRLTDREW AEEWKHLDHL LNCIMDMVEK TRRSLTVLRR
CQEADREELN YWIRRYSDAE DLKKGGGSSS SHSRQQSPVN PDPVALDAHR EFLHRPASGY
VPEEIWKKAE EAVNEVKRQA MTELQKAVSE AERKAHDMIT TERAKMERTV AEAKRQAAED
ALAVINQQED SSESCWNCGR KASETCSGCN TARYCGSFCQ HKDWEKHHHI CGQTLQAPQQ
GDTPAVSSSV TPSSGAGSPM DTPPAATPRS TTPGTPSTIE TTPR
//
