ID A0A1U7Q9I3_MESAU Unreviewed; 324 AA.
AC A0A1U7Q9I3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=GRB2-related adapter protein 2 isoform X1 {ECO:0000313|RefSeq:XP_005067060.1, ECO:0000313|RefSeq:XP_021081059.1};
GN Name=Grap2 {ECO:0000313|RefSeq:XP_005067060.1,
GN ECO:0000313|RefSeq:XP_021081059.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|RefSeq:XP_005067060.1};
RN [1] {ECO:0000313|RefSeq:XP_005067060.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
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DR RefSeq; XP_005067060.1; XM_005067003.3.
DR RefSeq; XP_021081059.1; XM_021225400.1.
DR STRING; 10036.ENSMAUP00000006317; -.
DR KEGG; maua:101835561; -.
DR eggNOG; KOG3601; Eukaryota.
DR OrthoDB; 25371at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR CDD; cd09941; SH2_Grb2_like; 1.
DR CDD; cd11950; SH3_GRAP2_C; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035646; GRAP2_C_SH3.
DR InterPro; IPR043539; Grb2-like.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46037:SF3; GRB2-RELATED ADAPTER PROTEIN 2; 1.
DR PANTHER; PTHR46037; PROTEIN ENHANCER OF SEVENLESS 2B; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 2.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..56
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 58..149
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 265..324
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 144..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..215
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 324 AA; 37355 MW; DE2F7FC37ABE7895 CRC64;
MEAIAKFDFM ASGEDELSFH TGDILKILSN QEEWLKAELG SQEGYVPKNF IDIEFPEWFH
EGLSRHQAEN LLMGKEIGFF IIRASQSSPG DFSISVRHED DVQHFKVMRD NKGNYFLWTE
KFPSLNKLVD YYRTTSISKQ KQIFLRDGTR EDQSHRGNSL DRKFQGSPQP SGNVGEETRP
LMNRKLSDNP PTRPQQYHQH QQPPPPFPPG PQHPPQRYLQ HHHFHQDRRG GSLDINDGHC
GIGGEMNATV MHRRHTDPVQ LQVAGRVRWA RALYDFEALE EDELGFRSGE VVEVLDSSNP
SWWTGRLHNK LGLFPANYVA PMTR
//
