ID A0A1U7QBP6_MESAU Unreviewed; 2202 AA.
AC A0A1U7QBP6;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Activating signal cointegrator 1 complex subunit 3 {ECO:0000256|ARBA:ARBA00014590};
GN Name=Ascc3 {ECO:0000313|RefSeq:XP_005070465.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005070465.1};
RN [1] {ECO:0000313|RefSeq:XP_005070465.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|ARBA:ARBA00008708}.
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DR RefSeq; XP_005070465.1; XM_005070408.3.
DR RefSeq; XP_012969057.1; XM_013113603.1.
DR STRING; 10036.ENSMAUP00000020291; -.
DR eggNOG; KOG0952; Eukaryota.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0099053; C:activating signal cointegrator 1 complex; IEA:Ensembl.
DR GO; GO:0022626; C:cytosolic ribosome; IEA:Ensembl.
DR GO; GO:1990391; C:DNA repair complex; IEA:Ensembl.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0006307; P:DNA dealkylation involved in DNA repair; IEA:Ensembl.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:Ensembl.
DR GO; GO:1990116; P:ribosome-associated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR CDD; cd18020; DEXHc_ASCC3_1; 1.
DR CDD; cd18022; DEXHc_ASCC3_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF13; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 2.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 487..670
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 697..915
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1337..1512
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1545..1740
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 2202 AA; 251307 MW; 50C34B43465546F9 CRC64;
MVLPRLTGAL RSFSNVTKKD NYNEEVADLK LKRSKLHEQV LELGLTWKKI VQFLNEKLEK
NKMQSINEDL KDILQAAKQI VGTDNGREAI ESGAAFLFMT FHLAESVGHM ETKAIRQMFG
PFPSSSAIAA CNATNRIISH FSQDDLTALV QMAENQCNDR VFFGKNLAFS FDMHGLDYFD
ELPINGEAQK TISLDYKKFL NGHFQEHYTP ELKPVEKTNG SFLWCEVEKY LNSTSKEMTE
TPRIEDLCCT LYDMLASVKS GDELQDELFE LLGPEGLDLI EKLLQNRITI VDRFLNSSND
HKFQVLQDSC KKILGENAKP NYGCQVTIQS EQEKQLMKLY RREEKRIARR EKKAGEDGEV
SGEGLLSFDP KELRIHREQA LLNARNAPIL GRQRDMEAEK IRYPHVYDSQ IEARETSAFI
AGAKMILPEG IQRENTKLYE EVRIPYSEPM PVGLEEKPVY IQDLDEIGQL AFKGMKRLNR
IQSIVFETAY NTNENMLICA PTGAGKTNIA MLTVLHEIRQ HFQQGVIKKN EFKIVYVAPM
KALAAEMTNY FSKRLEPLGI VVKELTGDMQ LSKSEILRTQ MLVTTPEKWD VVTRKSVGDV
ALSQIVKLLI LDEVHLLHED RGPVLESIVA RTLRQVESTQ SMIRILGLSA TLPNYLDVAT
FLHVNPYIGL FYFDGRFRPV PLGQTFLGIK SANKMQQLNN MDEVCYESVW KQVKAGHQVM
VFVHARNATV RTAMSLIERA KNSGQISYFL PTQGPEYGHA LKQVQRSRNK QVRELFLDGF
SIHHAGMLRQ DRNLVENLFS NGHIKVLVCT ATLAWGVNLP AHAVIIKGTQ IYAAKRGSFV
DLGILDVMQI FGRAGRPQFD KFGEGIIITT HDKLSHYLTL LTQQNPIESQ FLESLADNLN
AEIALGTVTN VEEAVKWISY TYLYVRMRAN PLAYGISQKA YQMDPTLRKH REQLVIEVGQ
KLDKAKMIRF EERTGYFSST DLGRTASHYY IKYNTIETFN ELFDAHKTEG DIFAIVSKAE
EFDQIKVREE EVEELDALLS NFCELSAPGG VENSYGKINI LLQTYISRGE MDSFSLISDS
AYVAQNAARI VRALFEIALR KRWPAMTYRL LNLSKVIDKR LWGWASPLRQ FSVLPPHILT
RLEEKNLTVD KLKDMRKDEI GHILHHVNIG LKVKQCVHQI PSVTMEASIQ PITRTVLRVS
LSIHPDFSWN DQVHGTVGEP WWIWVEDPTN DHIYHSEYFL ALKKQVVSKE AQLLVFTIPI
FEPLPSQYYI RAVSDRWLGA EAVCIINFQH LILPERHPPH TELLDLQPLP VTALGCRAYE
ALYNFSHFNP VQTQIFHTLY HTDCNVLLGA PTGSGKTVAA ELAIFRVFNK YPTSKAVYIA
PLKALVRERM DDWKVRIEEK LGKKVIELTG DVTPDMKSIA QADLIVTTPE KWDGVSRSWQ
NRNYVQQVTI LIIDEIHLLG EERGPVLEVI VSRTNFISSH TEKPVRIVGL STALANARDL
ADWLNIKQMG LFNFRPSVRP VPLEVHIQGF PGQHYCPRMA SMNKPAFQAI RSHSPAKPVL
IFVSSRRQTR LTALELIAFL ATEEDPKQWL NMDEQEMENI IGTIRDSNLK LTLAFGIGMH
HAGLHERDRK TVEELFVNCK VQVLIATSTL AWGVNFPAHL VIIKGTEYYD GKTRRYVDFP
ITDVLQMMGR AGRPQFDDQG KAVILVHDIK KDFYKKFLYE PFPVESSLLG VLSDHLNAEI
AGGTITSKQD AMDYITWTYF FRRLIMNPSY YNLDDVSHDS MNKFLSHLIE KSLVELELSH
CIEVGEDNRS IEPLEYGRIA SYYYLKHKTV KMFKDRLKPE CSTEELLSIL SDAEEYTDLP
VRHNEDHTNS ELAKCLPIEL NPHSFDSPHT KAHLLLQAHL SRAMLPCPDY DTDTKTVLDQ
ALRVCQAMLD VAASQGWLVT ALNITHLVQM VIQGRWLKDS SLLTIPNIEQ HHLHLFRKWK
PPVKSPHARW RTSIECLPEL IHACEGKDHV FNSMVENELQ STKAKQAWNF LSRLPVINVG
ISVKGSWDDS VEGHNELSIS TLTADKRDDN KWIKLHADQE YVLQVSLRRV HFGFHKGKHD
SYAVTPRFPK LKDEGWFLIL GEVDKRELIA LKRVGFVRTH HDISLSFCTP ETPGRYIFTL
YLMSDCYLGL DQQYDIYLNI TKANISSQVN TKVSDASTDL TV
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