ID A0A1U7QCT1_MESAU Unreviewed; 371 AA.
AC A0A1U7QCT1;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=CST complex subunit STN1 {ECO:0000256|ARBA:ARBA00017411, ECO:0000256|PIRNR:PIRNR036950};
DE AltName: Full=Oligonucleotide/oligosaccharide-binding fold-containing protein 1 {ECO:0000256|ARBA:ARBA00030852, ECO:0000256|PIRNR:PIRNR036950};
DE AltName: Full=Suppressor of cdc thirteen homolog {ECO:0000256|ARBA:ARBA00030039, ECO:0000256|PIRNR:PIRNR036950};
GN Name=Stn1 {ECO:0000313|RefSeq:XP_005063543.1,
GN ECO:0000313|RefSeq:XP_012975362.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005063543.1};
RN [1] {ECO:0000313|RefSeq:XP_005063543.1, ECO:0000313|RefSeq:XP_012975362.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the CST complex proposed to act as a specialized
CC replication factor promoting DNA replication under conditions of
CC replication stress or natural replication barriers such as the telomere
CC duplex. The CST complex binds single-stranded DNA with high affinity in
CC a sequence-independent manner, while isolated subunits bind DNA with
CC low affinity by themselves. Initially the CST complex has been proposed
CC to protect telomeres from DNA degradation. However, the CST complex has
CC been shown to be involved in several aspects of telomere replication.
CC {ECO:0000256|PIRNR:PIRNR036950}.
CC -!- SUBUNIT: Component of the CST complex. {ECO:0000256|PIRNR:PIRNR036950}.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR036950}.
CC -!- SIMILARITY: Belongs to the STN1 family.
CC {ECO:0000256|ARBA:ARBA00009698}.
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DR RefSeq; XP_005063543.1; XM_005063486.3.
DR RefSeq; XP_012975362.1; XM_013119908.2.
DR STRING; 10036.ENSMAUP00000016604; -.
DR GeneID; 101844063; -.
DR KEGG; maua:101844063; -.
DR CTD; 79991; -.
DR eggNOG; KOG3108; Eukaryota.
DR OrthoDB; 593927at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:1990879; C:CST complex; IEA:InterPro.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016233; P:telomere capping; IEA:InterPro.
DR GO; GO:0010833; P:telomere maintenance via telomere lengthening; IEA:UniProtKB-UniRule.
DR CDD; cd04483; hOBFC1_like; 1.
DR Gene3D; 1.10.10.980; CST, Suppressor of Cdc13 homolog, complex subunit STN1, N-terminal domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR015253; CST_STN1_C.
DR InterPro; IPR042082; CST_Stn1_wHTH1_sf.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR040260; RFA2-like.
DR InterPro; IPR014647; Stn1.
DR InterPro; IPR018856; Stn1_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13989:SF33; CST COMPLEX SUBUNIT STN1; 1.
DR PANTHER; PTHR13989; REPLICATION PROTEIN A-RELATED; 1.
DR Pfam; PF10451; Stn1; 1.
DR Pfam; PF09170; STN1_2; 1.
DR PIRSF; PIRSF036950; UCP036950; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|PIRNR:PIRNR036950};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR036950};
KW Nucleus {ECO:0000256|PIRNR:PIRNR036950};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Telomere {ECO:0000256|ARBA:ARBA00022895, ECO:0000256|PIRNR:PIRNR036950}.
FT DOMAIN 45..93
FT /note="CST complex subunit Stn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10451"
FT DOMAIN 207..371
FT /note="Stn1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09170"
SQ SEQUENCE 371 AA; 42487 MW; 01CD0D6C356F7EB7 CRC64;
MQCESSPRDE EIPSLFWGLD PVFLAFAKLY IRDILEMKES QQVPGVYIYN RHPIRRVDVL
GTVISVRERE TFYSYGVDDA TGVINCTCWK NLNNTKSSSD PAAPSTAREL TLTSQLKKLQ
ETIEQKTKIE IGDVIRVRGY VRMFREEREI CASLYYKVDD PVWNIQIARM LELPALYKKV
YDQPFRSPAS QGEEAPNNTD TLDLGGLTSL LSEKIKEFLQ EKKVQTFYQQ ELETVESLQS
LASQPVTHST CSNQVESKNC ATSGTIHGVF KNAIQLLQER GLVFQKDGGF DKPYYVTSKD
KDLHQKIYQI IKEDCQRPNH VEKGCHLMHI LKCVHLNLCW DLNKAVLQQV LELLEDQSDI
VSTGAHYYTA F
//
