ID A0A1U7QD12_MESAU Unreviewed; 289 AA.
AC A0A1U7QD12;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Tumor necrosis factor ligand superfamily member {ECO:0000256|PIRNR:PIRNR038013};
GN Name=Tnfsf10 {ECO:0000313|RefSeq:XP_005069814.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005069814.1};
RN [1] {ECO:0000313|RefSeq:XP_005069814.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|PIRNR:PIRNR038013}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670, ECO:0000256|PIRNR:PIRNR038013}.
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DR RefSeq; XP_005069814.1; XM_005069757.3.
DR AlphaFoldDB; A0A1U7QD12; -.
DR STRING; 10036.ENSMAUP00000014581; -.
DR GeneID; 101826873; -.
DR KEGG; maua:101826873; -.
DR CTD; 8743; -.
DR eggNOG; ENOG502QQ3R; Eukaryota.
DR OrthoDB; 5348190at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0045569; F:TRAIL binding; IEA:Ensembl.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR017355; TNF_ligand_10/11.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11471:SF27; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 10; 1.
DR Pfam; PF00229; TNF; 1.
DR PIRSF; PIRSF038013; TNF10_TNF11; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|PIRNR:PIRNR038013};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038013};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR038013-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|PIRSR:PIRSR038013-50}.
FT TRANSMEM 16..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 125..288
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT BINDING 238
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="ligand shared between all trimeric partners"
FT /evidence="ECO:0000256|PIRSR:PIRSR038013-50"
SQ SEQUENCE 289 AA; 33574 MW; CC113464293D3499 CRC64;
MPSTETLKGP SFGQHFWMMV ICTVLLQMLL QTLSVAMTYV YFTNEMKQLQ NKYSRSRLDC
LLKEDEDAWS PTEEEIQYCL QTRKQLYQLI EEVSLRTVKE TTSTVQEKQL SIPFPPRSGK
PQRVAAHITG ISRKSSSALA PMSKDGKTLG QKIESWESSR KGHSFLNYVL LRNGELVIQE
QGLYYIYSQT YFRFRENEEG SKTVSKDRGQ NKQMVQYIYK YTSYPDPIML MKSARNSCWS
RDAEYGLYSI YQGGLFELKE NDRIFVSVTN EHLMDLDQEA SFFGAFLIN
//
