ID A0A1U7QE54_MESAU Unreviewed; 528 AA.
AC A0A1U7QE54;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=COUP transcription factor 1 {ECO:0000313|RefSeq:XP_005065756.2};
GN Name=Nr2f1 {ECO:0000313|RefSeq:XP_005065756.2};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005065756.2};
RN [1] {ECO:0000313|RefSeq:XP_005065756.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily. {ECO:0000256|ARBA:ARBA00006421}.
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DR RefSeq; XP_005065756.2; XM_005065699.3.
DR AlphaFoldDB; A0A1U7QE54; -.
DR GeneID; 101838287; -.
DR KEGG; maua:101838287; -.
DR CTD; 7025; -.
DR OrthoDB; 5400963at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06958; NR_DBD_COUP_TF; 1.
DR CDD; cd06948; NR_LBD_COUP-TF; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24083:SF168; COUP TRANSCRIPTION FACTOR 1; 1.
DR PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01282; COUPTNFACTOR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 188..263
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 289..515
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 528 AA; 57862 MW; 540A1543A18B590C CRC64;
MPAAERGSRG PGCRRLGTGA QASGLHRCSR SARRGLAARQ SRVPCPHTLS RPGTLTSKDG
EMIAPHQAQA KVLQGRLDFI SRLRRPSEDW PFCPIPLSKV TDPQVPKKPL LLRYLPDRAG
FGRVLLLVPT VCGPVSEGGG TGGPSIPQAS GARTLTPQTP GQPGAPATPG TAGDKGQGPP
GSGQSQQHIE CVVCGDKSSG KHYGQFTCEG CKSFFKRSVR RNLTYTCRAN RNCPIDQHHR
NQCQYCRLKK CLKVGMRREA VQRGRMPPTQ PNPGQYALTN GDPLNGHCYL SGYISLLLRA
EPYPTSRYGS QCMQPNNIMG IENICELAAR LLFSAVEWAR NIPFFPDLQI TDQVSLLRLT
WSELFVLNAA QCSMPLHVAP LLAAAGLHAS PMSADRVVAF MDHIRIFQEQ VEKLKALHVD
SAEYSCLKAI VLFTSDACGL SDAAHIESLQ EKSQCALEEY VRSQYPNQPS RFGKLLLRLP
SLRTVSSSVI EQLFFVRLVG KTPIETLIRD MLLSGSSFNW PYMSIQCS
//
