ID A0A1U7QEL1_MESAU Unreviewed; 707 AA.
AC A0A1U7QEL1;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=T-cell activation Rho GTPase-activating protein {ECO:0000313|RefSeq:XP_005065981.1};
GN Name=Tagap {ECO:0000313|RefSeq:XP_005065981.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005065981.1};
RN [1] {ECO:0000313|RefSeq:XP_005065981.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005065981.1; XM_005065924.3.
DR AlphaFoldDB; A0A1U7QEL1; -.
DR STRING; 10036.ENSMAUP00000021260; -.
DR GeneID; 101833978; -.
DR KEGG; maua:101833978; -.
DR CTD; 117289; -.
DR eggNOG; KOG4724; Eukaryota.
DR OrthoDB; 2964977at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR PANTHER; PTHR23179:SF26; T-CELL ACTIVATION RHO GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 87..276
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 284..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 707 AA; 78576 MW; 8336475647B11514 CRC64;
MKLISSLHSK TLNAGNMETL IECQSEGDIK ALPLLTSCES EDSICQLIEV KKRKKVLSWP
SLMRKLSPSS DFSGSLEPEL KVSLFDQPLS IICGENDTLP RPIQDILTIL CLKGPSTEGI
FRKAASEKAR KELKEELNCG SPVNLNQLPV HLLAVVFKDF LRGIPLKLLS CDLFEEWMDA
LKKPSEEDRI EALKQVADRL PRPNLLLLRH LVYVLHLISK NAEVSKMDSS NLAICIGPNM
LTLKNDQSLS FQVQKDLNSK VKTLVEFLID NCFEIFGENI PTHSRITSDD SLEHTDSSDV
STLQNDSAYD SNDPDVEPPG AITSPSRQLE EPTATVADPD NRGSEDSCES NSELAVSLVA
RLKSSIGQPD RRFSEPNTSP SQECRTAQTT KQKLTRSEDS FAMPREACFE GDGAEDPFSE
EVFPAVEDKP QRPADLKIKN LTQGLASPQG WVPKALSRVS PGKSLDSSPI PSPSCPKRSF
FTRHQSFTTK TDKIKPQREI RKHSMSFSFT SHKKVLPRTS STGSEKSTDF SRDQIKKGLR
KDSQLAGRII QENESESQSY SLSGTWALSV DNVFQLIDVR KPGSPPSYAE AIHYQTSGLT
AYSGQTVSSM RARMLKWNTA LPPLPSRLGG DHCEGTPGGH TPSPMTERWE QSQTASLSVE
TQGRSELHRL RTVSETMQKA TLDCLRRQHR RMVFEVGQLQ CAKESYI
//
