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Database: UniProt
Entry: A0A1U7QHI7_MESAU
LinkDB: A0A1U7QHI7_MESAU
Original site: A0A1U7QHI7_MESAU 
ID   A0A1U7QHI7_MESAU        Unreviewed;      2733 AA.
AC   A0A1U7QHI7;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   13-FEB-2019, entry version 11.
DE   SubName: Full=inositol 1,4,5-trisphosphate receptor type 1 isoform X8 {ECO:0000313|RefSeq:XP_005066234.1};
GN   Name=Itpr1 {ECO:0000313|RefSeq:XP_005066234.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005066234.1};
RN   [1] {ECO:0000313|RefSeq:XP_005066234.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (DEC-2018) to UniProtKB.
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DR   RefSeq; XP_005066234.1; XM_005066177.1.
DR   GeneID; 101836776; -.
DR   CTD; 3708; -.
DR   Proteomes; UP000189706; Genome assembly.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000189706};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_005066234.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2258   2280       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2292   2310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2379   2404       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2424   2446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2554   2577       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    358       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      364    420       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1578   1598       {ECO:0000256|SAM:Coils}.
FT   COILED     2671   2712       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2733 AA;  311260 MW;  A038772FA84AFFD0 CRC64;
     MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL
     CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV
     IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD
     KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV
     RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
     SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS SIFELDPTTL
     RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM LKIGTSPLKE DKEAFAIVPV
     SPAEVRDLDF ANDASKVLGS IAGKLEKGTI TQNERRSVTK LLEDLVYFVT GGTNSGQDVL
     EVVFSKPNRE RQKLMREQNI LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL
     CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI
     DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL IETKLVLSRF
     EFEGVATGEN ALEAGEDEEE VWLFWRDSNK EIRSKSVREL AQDAKEGQKE DRDILSYYRY
     QLNLFARMCL DRQYLAINEI SGQLDVDLIL RCMSDENLPY DLRASFCRLM LHMHVDRDPQ
     EQVTPVKYAR LWSEIPSEIA IDDYDSSGAS KDEIKERFAQ TMEFVEEYLR DVVCQRFPFS
     DKEKNKLTFE VVNLARNLIY FGFYNFSDLL RLTKILLAIL DCVHVTTIFP ISKMAKGEEN
     KGSNVMRSIH GVGELMTQVV LRGGGFLPMT PMAAAPEGNV KQAEPEKEDI MVMDTKLKII
     EILQFILNVR LDYRISCLLC IFKREFDESN SQSSETSSGN SSQEGPSNVP GALDFEHIEE
     QAEGIFGGSE ENTPLDLDDH GGRTFLRVLL HLTMHDYPPL VSGALQLLFR HFSQRQEVLQ
     AFKQVQLLVT SQDVDNYKQI KQDLDQLRSI VEKSELWVYK GQGPDETMDG ASGENEHKKT
     EEGSSKPQKH ESTSSYNYRV VKEILIRLSK LCVQESASVR KSRKQQQRLL RNMGAHAVVL
     ELLQIPYEKA EDTKMQEIMR LAHEFLQNFC AGNQQNQALL HKHINLFLNP GILEAVTMQH
     IFMNNFQLCS EINERVVQHF VHCIETHGRN VQYIKFLQTI VKAEGKFIKK CQDMVMAELV
     NSGEDVLVFY NDRASFQTLI QMMRSERDRM DENSPLMYHI HLVELLAVCT EGKNVYTEIK
     CNSLLPLDDI VRVVTHEDCI PEVKIAYINF LNHCYVDTEV EMKEIYTSNH MWKLFENFLV
     DICRACNNTS DRKHADSILE KYVTEIVMSI VTTFFSSPFS DQSTTLQTRQ PVFVQLLQGV
     FRVYHCNWLM PSQKASVESC IRVLSDVAKS RAIAIPVDLD SQVNNLFLKS HNIVQKTAMN
     WRLSARNAAR RDSVLAASRD YRNIIERLQD IVSALEDRLR PLVQAELSVL VDVLHRPELL
     FPENTDARRK CESGGFICKL IKHTKQLLEE NEEKLCIKVL QTLREMMTKD RGYGEKQISI
     DEVENAELPQ APEAENSTEE LEPSPPLRQL EDHKRGEALR QILVNRYYGN IRPSGRRESL
     TSFGNGPLSP GGPSKPGGGG GGPGSSSTSR GEMSLAEVQC HLDKEGASNL VIDLIMNASS
     DRVFHESILL AIALLEGGNT TIQHSFFCRL TEDKKSEKFF KVFYDRMKVA QQEIKATVTV
     NTSDLGNKKK DDEVDRDAPS RKKAKEPTTQ ITEEVRDQLL EASAATRKAF TTFRREADPD
     DHYQSGEGTQ AATDKTKDDL EMSAVITIMQ PILRFLQLLC ENHNRDLQNF LRCQNNKTNY
     NLVCETLQFL DCICGSTTGG LGLLGLYINE KNVALINQTL ESLTEYCQGP CHENQNCIAT
     HESNGIDIIT ALILNDINPL GKKRMDLVLE LKNNASKLLL AIMESRHDSE NAERILYNMR
     PKELVEVIKK AYMQGEVEFE DGENGEDGAA SPRNVGHNIY ILAHQLARHN KELQTMLKPG
     GQVDGDEALE FYAKHTAQIE IVRLDRTMEQ IVFPVPSICE FLTKESKLRI YYTTERDEQG
     SKINDFFLRS EDLFNEMNWQ KKLRAQPVLY WCARNMSFWS SISFNLAVLM NLLVAFFYPF
     KGVRGGTLEP HWSGLLWTAM LISLAIVIAL PKPHGIRALI ASTILRLIFS VGLQPTLFLL
     GAFNVCNKII FLMSFVGNCG TFTRGYRAMV LDVEFLYHLL YLLICAMGLF VHEFFYSLLL
     FDLVYREETL LNVIKSVTRN GRSIILTAVL ALILVYLFSI VGYLFFKDDF ILEVDKLPNE
     TALPETGESL ANDFLYSDVC RVETGENCTS PAPKEELLPV EETEQEKEHT CETLLMCIVT
     VLSHGLRSGG GVGDVLRKPS KEEPLFAARV IYDLLFFFMV IIIVLNLIFG VIIDTFADLR
     SEKQKKEEIL KTTCFICGLE RDKFDNKTVT FEEHIKEEHN MWHYLCFIVL VKVKDSTEYT
     GPESYVAEMI RERNLDWFPR MRAMSLVSSD SEGEQNELRN LQEKLESTMK LVTNLSGQLS
     ELKDQMTEQR KQKQRIGLLG HPPHMNVNPQ QPA
//
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