ID A0A1U7QJB9_MESAU Unreviewed; 561 AA.
AC A0A1U7QJB9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Acid-sensing ion channel 1 isoform X4 {ECO:0000313|RefSeq:XP_005067286.1};
GN Name=Asic1 {ECO:0000313|RefSeq:XP_005067286.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005067286.1};
RN [1] {ECO:0000313|RefSeq:XP_005067286.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. ASIC1 subfamily. {ECO:0000256|ARBA:ARBA00038517}.
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DR RefSeq; XP_005067286.1; XM_005067229.3.
DR AlphaFoldDB; A0A1U7QJB9; -.
DR GeneID; 101823620; -.
DR KEGG; maua:101823620; -.
DR CTD; 41; -.
DR eggNOG; KOG4294; Eukaryota.
DR OrthoDB; 3415680at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 2.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF170; ACID-SENSING ION CHANNEL 1; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022461}.
FT REGION 12..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 561 AA; 62540 MW; 8D372923A76DA9A9 CRC64;
MPIQIFCSVS FSSGEEAPGP MGDIWGPHQQ QQQQQESSES EEEEEEKEKE ALKRELDEGD
SPRDLVAFAN SCTLHGASHV FVEGGPGPRQ ALWAVAFVIA LGAFLCQVGD RVAYYLSYPH
VTLLDEVATT ELVFPAVTLC NTNAVRLSQL SYPDLLYLAP MLGLDESDDP GVPLAPPGPE
AFSGEPFNLH RFYNRSCHRL EDMLLYCSYC GGPCGPHNFS VVFTRYGKCY TFNSGQDGRP
RLKTMKGGTG NGLEIMLDIQ QDEYLPVWGE TDETSFEAGI KVQIHSQDEP PFIDQLGFGV
APGFQTFVSC QEQRLIYLPS PWGTCNAVTM DSDFFDSYSI TACRIDCETR YLVENCNCRM
VHMPGDAPYC TPEQYKECAD PALDFLVEKD QEYCVCEMPC NLTRYGKELS MVKIPSKASA
KYLAKKFNKS EQYIGENILV LDIFFEVLNY ETIEQKKAYE IAGLLGDIGG QMGLFIGASI
LTVLELFDYA YEVIKHRLCR RGKCQKEAKR SSADKGVALS LDDVKRHNPC ESLRGHPAGM
TYAANILPHH PARGTFEDFT C
//
