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Database: UniProt
Entry: A0A1U7QJG3_MESAU
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Original site: A0A1U7QJG3_MESAU 
ID   A0A1U7QJG3_MESAU        Unreviewed;       240 AA.
AC   A0A1U7QJG3;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Insulin-like growth factor-binding protein 6 {ECO:0000313|RefSeq:XP_005067352.1};
GN   Name=Igfbp6 {ECO:0000313|RefSeq:XP_005067352.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005067352.1};
RN   [1] {ECO:0000313|RefSeq:XP_005067352.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR   RefSeq; XP_005067352.1; XM_005067295.3.
DR   AlphaFoldDB; A0A1U7QJG3; -.
DR   STRING; 10036.ENSMAUP00000019871; -.
DR   GeneID; 101838993; -.
DR   KEGG; maua:101838993; -.
DR   CTD; 3489; -.
DR   eggNOG; ENOG502QV3Q; Eukaryota.
DR   OrthoDB; 5394492at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0042568; C:insulin-like growth factor binary complex; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0031995; F:insulin-like growth factor II binding; IEA:Ensembl.
DR   GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR   GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; IEA:Ensembl.
DR   CDD; cd00191; TY; 1.
DR   Gene3D; 4.10.40.20; -; 1.
DR   Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR022326; IGFBP-6.
DR   InterPro; IPR000867; IGFBP-like.
DR   InterPro; IPR022321; IGFBP_1-6_chordata.
DR   InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR   InterPro; IPR000716; Thyroglobulin_1.
DR   InterPro; IPR036857; Thyroglobulin_1_sf.
DR   PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR   PANTHER; PTHR11551:SF14; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 6; 1.
DR   Pfam; PF00086; Thyroglobulin_1; 1.
DR   PRINTS; PR01976; IGFBPFAMILY.
DR   PRINTS; PR01982; IGFBPFAMILY6.
DR   SMART; SM00121; IB; 1.
DR   SMART; SM00211; TY; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR   PROSITE; PS00222; IGFBP_N_1; 1.
DR   PROSITE; PS51323; IGFBP_N_2; 1.
DR   PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR   PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00500}; Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..240
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010563142"
FT   DOMAIN          26..108
FT                   /note="IGFBP N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51323"
FT   DOMAIN          159..234
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51162"
FT   REGION          106..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..137
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..240
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        214..234
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ   SEQUENCE   240 AA;  25588 MW;  B2C24D91A8C11AB0 CRC64;
     MTGNSLPPQP LLLMLTLLLA ASSGFALTRC PGCGPGVQTS CRGGCVEEED VGSPTEGCTE
     AGGCLRREGQ PCGVYIPKCA PGLQCQPREN EEAPLRALLM GQGRCHRARG LSEETTKESK
     PHGGASRQRD TSHRDRQKNP GTSTTPIRPN PGSVHDTEMG PCRRHLDSVL QGLQTEIFRG
     GAPGLYMPNC DLRGFYRKQQ CRSSQGNRRG PCWCVDPMGR PLPGSPDGQG SSQCSAKTSG
//
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