ID A0A1U7QKP7_MESAU Unreviewed; 411 AA.
AC A0A1U7QKP7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Transmembrane protease serine 11C-like {ECO:0000313|RefSeq:XP_005068169.1};
GN Name=LOC101823178 {ECO:0000313|RefSeq:XP_005068169.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005068169.1};
RN [1] {ECO:0000313|RefSeq:XP_005068169.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
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DR RefSeq; XP_005068169.1; XM_005068112.1.
DR AlphaFoldDB; A0A1U7QKP7; -.
DR STRING; 10036.ENSMAUP00000006502; -.
DR eggNOG; KOG3627; Eukaryota.
DR OrthoDB; 4629979at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF13; TRANSMEMBRANE SERINE PROTEASE 12; 1.
DR Pfam; PF01390; SEA; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF82671; SEA domain; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50024; SEA; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000313|RefSeq:XP_005068169.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000313|RefSeq:XP_005068169.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|RefSeq:XP_005068169.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..177
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 211..410
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 411 AA; 46247 MW; A09034EECE1BEEDD CRC64;
MARGQPRRSE EPWTSLQNRT ESKTKVRLTR CGKITLVILM TVVAAVVIGL IAYFVACGKP
PFYYHVSFKV NNIDYDSKFA KSYSEEYMDL NKKIVFLMNE TFHESKLRKQ YVKSHTVQVS
KANGKVVIHA VLKFKACYKN NVEKFWDRIE SILYQKLKSQ TGLLIDPSSF RFSGYRELIF
HFSIISRKTF PATASNGKSG YQQLSTYKII KWAILMKEEM GVVKDANPKD WKVSFGLLLS
KPQMQRTVKN IIIHENYSYP AHDNDIAVVH LSSPVLFASN IRRACLPEVT QKFPPNSDVV
VTGWGTLKSD GESPNILQKG RVKIIDNKTC NSGKAYGGVI TPGMLCAGFL EGRVDACQGD
SGGPLVSEDS NGIWFLAGIV SWGDECALPN KPGVYTRVTY YRDWITSKTG L
//
