ID A0A1U7QM89_MESAU Unreviewed; 1171 AA.
AC A0A1U7QM89;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Protocadherin-12 {ECO:0000313|RefSeq:XP_005069115.1};
GN Name=Pcdh12 {ECO:0000313|RefSeq:XP_005069115.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005069115.1};
RN [1] {ECO:0000313|RefSeq:XP_005069115.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005069115.1; XM_005069058.3.
DR AlphaFoldDB; A0A1U7QM89; -.
DR STRING; 10036.ENSMAUP00000017754; -.
DR GeneID; 101831926; -.
DR KEGG; maua:101831926; -.
DR CTD; 51294; -.
DR eggNOG; KOG3594; Eukaryota.
DR OrthoDB; 4259465at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:Ensembl.
DR GO; GO:0005977; P:glycogen metabolic process; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:Ensembl.
DR GO; GO:0060711; P:labyrinthine layer development; IEA:Ensembl.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF42; PROTOCADHERIN-12; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1171
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010571320"
FT TRANSMEM 716..739
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..135
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 136..244
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 245..352
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 355..460
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 461..565
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 618..717
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 855..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1074..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1171 AA; 127048 MW; E0CFC79CEFEA906F CRC64;
MMLLLPFLLG LLGPGSYLFL SGDCQEVATL MVKFQVTEEV PSGTVVGRLS QERGVEERRG
KAGDAFQILQ LPQALPIQMK SEDGLLSTSS RLDREQLCRQ QDPCLVSFDV LATGASALIH
VEIQVLDIND HQPQFPKGEQ ELEISESASL HTRIPLDRAL DQDTGSNSLY SYSLSPSEHF
ALDVIVGPDE TKHAELVVMK ELDREVHSFF DLVLTAYDNG NPPKSGTSVV KVNVLDSNDN
SPVFAESSLA LEIPEDTAPG TLLINLTATD PDQGPNGEVE FFFGKHVSSE VMNTFGVDAK
TGQIILRQAL DYEKNPAYEV DVQARDLGPN SIPGHCKVLI KVLDVNDNAP SIHVTWASQT
SLVSEDIPKD SFIALVSAND LDSGNNGLVH CWLNQELGHF RLKRTNGNTY MLLTNTTLDR
EQWSVYTLTV FAQDQGPQPL SAEKDLRIQV DDVNDNAPVF EKSRYEVSTW ENNPPSLHLI
TIKAHDADLG INGKVSYHIK DSPVSHLVAI DSETGEVTAQ KSLDYEQMAG FEFQVIAEDR
GQPQLASSMS VWVSLLDAND NAPEVIQPVL SEGKATLSVL VNASTGHLLL PIENPRGLDP
AVTGTAPIAT HSPWPFLLVT IVARDADSGA NGELLYSIRS GNDAHLFILS PSRGQLFINV
TNASGLIGSQ WDLGIVVEDQ GSPSLQTQVL LRVVFVTSVD HLRDSAREPG VLSTPVLATI
CLAALLAIFG LILALFVSIC RTEKRDNRAY NCREAESTYR HQPKRPQKHI QKADIHLVPM
LRAQEGEADE VRSSHKDTSK EALMETGWDP CLQAPFHLTP TLYRTLRNQG NQGALAESQE
GLQDTFNFLF SHPRQRNASR ENLSLPEGPP ALGQPHLRPL KVPGSPVARL AGDQGSEEAL
QSPPSSSATL RRQRNLNSKA SPKGESGPHQ ILRSLVRLSV AAFAERNPVE ELAGDSPPVQ
QISQLLSLLH QGQFQPKPNH RGNKYLAKPG GSRATSPDAD GPGVRPGGQA EADLEEAPLG
TEEDLSVKRL LEEELSSLLD PHTGLALDKL STPDPAWMAR LSLPLTTNYR DNLSSPDAAA
SEEPRTFQTF GKPAGPGPEL SPAGTRLAST FVSEMSSLLE MLLEQHTVPV EAASAALRRL
SVCGRTLSLD LATRGASGSE AEGRLGRGGN L
//
