ID   A0A1U7QRL0_MESAU        Unreviewed;       878 AA.
AC   A0A1U7QRL0;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Multiple C2 and transmembrane domain-containing protein 2 isoform X1 {ECO:0000313|RefSeq:XP_005084603.1};
GN   Name=Mctp2 {ECO:0000313|RefSeq:XP_005084603.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005084603.1};
RN   [1] {ECO:0000313|RefSeq:XP_005084603.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   RefSeq; XP_005084603.1; XM_005084546.3.
DR   AlphaFoldDB; A0A1U7QRL0; -.
DR   STRING; 10036.ENSMAUP00000000215; -.
DR   GeneID; 101842652; -.
DR   KEGG; maua:101842652; -.
DR   CTD; 55784; -.
DR   eggNOG; KOG1030; Eukaryota.
DR   OrthoDB; 880291at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR   CDD; cd04042; C2A_MCTP_PRT; 1.
DR   CDD; cd08376; C2B_MCTP_PRT; 1.
DR   CDD; cd08377; C2C_MCTP_PRT; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 3.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR013583; MCTP_C.
DR   PANTHER; PTHR45911; C2 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45911:SF2; MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF00168; C2; 3.
DR   Pfam; PF08372; PRT_C; 1.
DR   PRINTS; PR00360; C2DOMAIN.
DR   SMART; SM00239; C2; 3.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR   PROSITE; PS50004; C2; 3.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        692..719
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        793..814
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          177..292
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          338..452
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          486..607
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          20..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          64..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          728..754
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..100
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..160
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..176
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   878 AA;  99775 MW;  108180AB4E4B00B6 CRC64;
     MDMDKPSVWG SLKQRTRPLL INLSKKKAKK TPSKPLDLKV QHHLDRRLSL SVPDLLEAEA
     LAPEGLPYSG PQSSYTSVPN SLSTAGIVPK SSSSSLKQSE EELDWSQEEA SLVHGLDTDS
     EEIYASSVEE RPASSQSGLD MHKQPLGGDA PEEPEKSHGN DDLNASMTSQ NFEEESTLGE
     AGDCLSHLPS PFAYLLTIHL KEGRNLVVRD RCGTSDPYVK FKLNGKTLYK SKVIYKNLNP
     IWDEIVVLPI HSLDQKLRVK VYDRDLTTSD FMGSAFVILR DLELNRTTEH ILKLEDPNSL
     EDDMGVIVLN LNLVVKQGDF KRHRWSNRKR LSASKSYLIR NLRLSESLRK NQLWNGIISI
     TLLEGKNVSG GNMSEMFVQL KLGDQRYKSK TLCKSANPQW QEQFDFHYFS DRMGILDIEV
     WGKDSKKHEE RLGTCKVDIS ALPLKQENCL ELPLESCLGA LIMLITLTPC TGVSISDLCV
     CPLEDPSERK QISQRYALQN SLKNVKDVGI LQVKVLKAAD LLAADFSGKS DPFCLLELGN
     DRLQTHTIYK SLNPEWNKVF TFPIKDIHDV LEVTVFDEDG DKAPDFLGKV AIPLLSIRDG
     QPNCYVLKNK DLEQAFKGLL YLEMDLIYNP VKASIRTFAP KEKRFVEDSR KLSKKILSRD
     ADRVKRLTMA VWNTIQFFKS CFQWESTLRS SIAFVVFLVT VWNFELYMIP LALLLIFLYN
     FLRPTKGKAN STQDSQESTD IDEEEEEEEK ESEKKGLIER IYMVQDIVST VQNILEEVAS
     FGERIKNMFN WTVPFLSLLA CLILAIATVA LYFIPLRYIV LLWGINKFTK KLRNPYAIDN
     NELLDFLSRV PSDIQKVQYA ELKLCGSHSP LRKKRNTV
//