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Database: UniProt
Entry: A0A1U7QSK3_MESAU
LinkDB: A0A1U7QSK3_MESAU
Original site: A0A1U7QSK3_MESAU 
ID   A0A1U7QSK3_MESAU        Unreviewed;       375 AA.
AC   A0A1U7QSK3;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   05-JUN-2019, entry version 16.
DE   SubName: Full=ATP-sensitive inward rectifier potassium channel 15 isoform X2 {ECO:0000313|RefSeq:XP_005073849.1, ECO:0000313|RefSeq:XP_012971687.1, ECO:0000313|RefSeq:XP_012971688.1};
GN   Name=Kcnj15 {ECO:0000313|RefSeq:XP_005073849.1,
GN   ECO:0000313|RefSeq:XP_012971687.1, ECO:0000313|RefSeq:XP_012971688.1,
GN   ECO:0000313|RefSeq:XP_012971689.1, ECO:0000313|RefSeq:XP_012971690.1,
GN   ECO:0000313|RefSeq:XP_021085081.1, ECO:0000313|RefSeq:XP_021085082.1,
GN   ECO:0000313|RefSeq:XP_021085083.1, ECO:0000313|RefSeq:XP_021085084.1,
GN   ECO:0000313|RefSeq:XP_021085085.1, ECO:0000313|RefSeq:XP_021085086.1,
GN   ECO:0000313|RefSeq:XP_021085087.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005073849.1};
RN   [1] {ECO:0000313|RefSeq:XP_005073849.1, ECO:0000313|RefSeq:XP_012971687.1, ECO:0000313|RefSeq:XP_012971688.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (DEC-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   RefSeq; XP_005073849.1; XM_005073792.1.
DR   RefSeq; XP_012971687.1; XM_013116233.1.
DR   RefSeq; XP_012971688.1; XM_013116234.1.
DR   RefSeq; XP_012971689.1; XM_013116235.1.
DR   RefSeq; XP_012971690.1; XM_013116236.1.
DR   RefSeq; XP_021085081.1; XM_021229422.1.
DR   RefSeq; XP_021085082.1; XM_021229423.1.
DR   RefSeq; XP_021085083.1; XM_021229424.1.
DR   RefSeq; XP_021085084.1; XM_021229425.1.
DR   RefSeq; XP_021085085.1; XM_021229426.1.
DR   RefSeq; XP_021085086.1; XM_021229427.1.
DR   RefSeq; XP_021085087.1; XM_021229428.1.
DR   STRING; 10036.XP_005073849.1; -.
DR   GeneID; 101823816; -.
DR   CTD; 3772; -.
DR   Proteomes; UP000189706; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003270; K_chnl_inward-rec_Kir1.3.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF20; PTHR11767:SF20; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01323; KIR13CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000189706};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|RefSeq:XP_005073849.1,
KW   ECO:0000313|RefSeq:XP_012971687.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     67     88       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    142    166       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       30    171       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      178    348       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   COILED      348    368       {ECO:0000256|SAM:Coils}.
FT   SITE        157    157       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   375 AA;  42610 MW;  66537F7985A6348D CRC64;
     MDTMHVGMSS APLVKHSNGV GLKAHRPRVM SKSGHSNVRI DKVDGIYLLY LQDLWTTVID
     MKWRYKLTLF AATFVMTWFL FGVVYYAIAF IHGDLELGEP NSSHTPCIME VDSLTGAFLF
     SLESQTTIGY GVRSITEECP HAIFLLVAQL VITTLIEIFI TGTFLAKIAR PKKRAETIKF
     SHCAVISKQN GKLCLVIQVA NMRKSLLIQC QLSGKLLQTH ITKEGERILL NQATVKFHVD
     SSSESPFLIL PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY
     IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQK LEEQYRQEDQ
     RDRELRSLLL QQSNV
//
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