ID   A0A1U7QSR2_MESAU        Unreviewed;       813 AA.
AC   A0A1U7QSR2;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Calpain-7 {ECO:0000313|RefSeq:XP_005085284.1};
GN   Name=Capn7 {ECO:0000313|RefSeq:XP_005085284.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005085284.1};
RN   [1] {ECO:0000313|RefSeq:XP_005085284.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C2 family.
CC       {ECO:0000256|ARBA:ARBA00007623}.
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DR   RefSeq; XP_005085284.1; XM_005085227.3.
DR   AlphaFoldDB; A0A1U7QSR2; -.
DR   STRING; 10036.ENSMAUP00000021678; -.
DR   GeneID; 101823600; -.
DR   KEGG; maua:101823600; -.
DR   CTD; 23473; -.
DR   eggNOG; KOG0045; Eukaryota.
DR   OrthoDB; 230045at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0090541; F:MIT domain binding; IEA:Ensembl.
DR   GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
DR   GO; GO:0097264; P:self proteolysis; IEA:Ensembl.
DR   CDD; cd00044; CysPc; 1.
DR   CDD; cd02681; MIT_calpain7_1; 1.
DR   Gene3D; 2.60.120.380; -; 2.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 2.
DR   InterPro; IPR022684; Calpain_cysteine_protease.
DR   InterPro; IPR022682; Calpain_domain_III.
DR   InterPro; IPR022683; Calpain_III.
DR   InterPro; IPR036213; Calpain_III_sf.
DR   InterPro; IPR007330; MIT_dom.
DR   InterPro; IPR036181; MIT_dom_sf.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR   PANTHER; PTHR46143; CALPAIN-7; 1.
DR   PANTHER; PTHR46143:SF1; CALPAIN-7; 1.
DR   Pfam; PF01067; Calpain_III; 1.
DR   Pfam; PF04212; MIT; 2.
DR   Pfam; PF00648; Peptidase_C2; 1.
DR   PRINTS; PR00704; CALPAIN.
DR   SMART; SM00720; calpain_III; 1.
DR   SMART; SM00230; CysPc; 1.
DR   SMART; SM00745; MIT; 2.
DR   SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 2.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF116846; MIT domain; 2.
DR   PROSITE; PS50203; CALPAIN_CAT; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00239}; Protease {ECO:0000256|PROSITE-ProRule:PRU00239};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Thiol protease {ECO:0000256|PROSITE-ProRule:PRU00239}.
FT   DOMAIN          260..540
FT                   /note="Calpain catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50203"
FT   ACT_SITE        290
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        458
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        478
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
SQ   SEQUENCE   813 AA;  92619 MW;  C1910C1612CBCB10 CRC64;
     MDATALERDA VQFARLAVQR DHEGRYSEAV FYYKEAAQAL IYAEMAGSSL ERIQEKISEY
     LERVQALHSA VQSKSADPLK SKHQLDLERA HFLVTQAFDE DEKGSVEDAI ELYTEAVDLC
     LKTSYETADK TLQNKLKQLA RQALDRAEAL SEPLTKPFCK LKSTNMKTKT PAVRTHFPLG
     PNPFHEKPQP FISPQSCDAQ GQRYTAEEIE VLRTTSKING IEYVPFMSVD LRERFAYPMP
     FCDRWGKLPL SPKQTATFSK WVRPEDLTNN PTMIYTVSSF SIKQTIVSDC SFVASLAISA
     AYERRFNKKL ITSIIYPQNK DGEPEYNPCG KYMVKLHLNG VPRKVIIDDQ LPVDHKGELL
     CSYSNNKSEL WVSLIEKAYM KVMGGYDFPG SNSNIDLHAL TGWIPERIAM HSDSQTFSKD
     SSFRMLYQRF HKGDVLITAS TGTMTEAEGE RWGLVPTHAY AVLDIREFKG LRFIQLKNPW
     SHLRWKGRYS ENDVKNWTPE LQKYLNFDPR TAQKIDNGIF WISWDDLCQY YDVVYLSWNP
     SLFKESTCIH STWDAKQGPV KDAYSLANNP QYKLEVQCPQ GGAAVWVLLS RHITDKDDFA
     NNREFITMVV YKTDGKKVYY PADPPPYIDG IRINSPHYLT KIKLTTPGTH TFTLVVSQYE
     KQNTIHYTVR VYSACSFTFS KIPSPYTLSK RINGKWSGQS AGGCGNFQET HKNNPIYQFH
     VDKTGPLLIE LRGPRQYSVG FEVVAVSITG DSGPHGFQRK SSGDYRCGFC YLELENIPAG
     VFNIVPSTFL PKQEGPFFLD FNSTVPIKTT QLQ
//