ID A0A1U7QWQ4_MESAU Unreviewed; 720 AA.
AC A0A1U7QWQ4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Engulfment and cell motility protein 3 isoform X2 {ECO:0000313|RefSeq:XP_005076332.1};
GN Name=Elmo3 {ECO:0000313|RefSeq:XP_005076332.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005076332.1};
RN [1] {ECO:0000313|RefSeq:XP_005076332.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR RefSeq; XP_005076332.1; XM_005076275.2.
DR AlphaFoldDB; A0A1U7QWQ4; -.
DR STRING; 10036.ENSMAUP00000020847; -.
DR GeneID; 101825152; -.
DR KEGG; maua:101825152; -.
DR CTD; 79767; -.
DR eggNOG; KOG2999; Eukaryota.
DR OrthoDB; 4872856at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR Gene3D; 6.10.250.810; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR PANTHER; PTHR12771:SF16; ENGULFMENT AND CELL MOTILITY PROTEIN 3; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 307..479
FT /note="ELMO"
FT /evidence="ECO:0000259|PROSITE:PS51335"
SQ SEQUENCE 720 AA; 81469 MW; EEF1016B3591EDDB CRC64;
MAPPRNVVKI AVQKSDAIPQ LIQLDQAKPL ATVLKEVCDA WNLPHSESYA LKFADGHKRY
ITENNRMEIK NGSILCLSTA PDLEAQQVLG GLQSASREGC YQALKNLVPL ASDMTFAQEV
ISRDGLQRLS TIIENGDDLG EMLALGLTAF LELMEHGVVS WETLSIPFVR KVVSYVNMNL
MDASVQPLAL RLLESVTLSS PALGQLVKSE VPLDRLLVHL QVVNQQLQTK AMALLTALLQ
GASTAERKHM LDYLWKRNLR QFIYKNIIHS AAPMGDEMAH HLYVLQALTL GLLEPRMRTP
LDPYNQEERE RLQALRQAAF EPEGESSGTG LSADRRRSLC VREFRKLGFS NSNPAQDLER
VPPGLLALDN MLYFSKHAPS AYSRFVLENS SREDKHECPF AKSSIQLTVV LCELLHVGEP
CSETAQDFSP MFFSQDHSFH ELFCVAIQLL NKTWKEMRAT QEDFDKVMQV VREQLARTLA
LKPTSLELFR TKVNVLSYGE VLRLRQTERL HQEGTLAPPI LELREKLKPQ LMGLIRQQRL
LRLCEGMLFR KISSRRRQDK LWFCCLSPNH KVLQYGDVEE GANPPTLESL PEQLPVADIR
ALLMGKDCPH VREKGSGKQN KDLYELAFSI SYDHGEEEAY LNFIAPSKRD FYLWTDGLSA
LLGSTMGSEQ TRLDLEQLLT METKLRLLEL ENVPIPEQPP PVPPPPTNFN FCYDFSITEP
//
