GenomeNet

Database: UniProt
Entry: A0A1U7QZQ4_MESAU
LinkDB: A0A1U7QZQ4_MESAU
Original site: A0A1U7QZQ4_MESAU 
ID   A0A1U7QZQ4_MESAU        Unreviewed;       855 AA.
AC   A0A1U7QZQ4;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=Suppressor of tumorigenicity 14 protein homolog {ECO:0000256|PIRNR:PIRNR036370};
DE            EC=3.4.21.109 {ECO:0000256|PIRNR:PIRNR036370};
DE   AltName: Full=Serine protease 14 {ECO:0000256|PIRNR:PIRNR036370};
GN   Name=St14 {ECO:0000313|RefSeq:XP_005084503.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005084503.1};
RN   [1] {ECO:0000313|RefSeq:XP_005084503.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Exhibits trypsin-like activity as defined by cleavage of
CC       synthetic substrates with Arg or Lys as the P1 site.
CC       {ECO:0000256|PIRNR:PIRNR036370}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Cleaves various synthetic substrates with Arg or Lys at the P1
CC         position and prefers small side-chain amino acids, such as Ala and
CC         Gly, at the P2 position.; EC=3.4.21.109;
CC         Evidence={ECO:0000256|PIRNR:PIRNR036370};
CC   -!- SUBUNIT: Interacts with CDCP1. May interact with TMEFF1.
CC       {ECO:0000256|PIRNR:PIRNR036370}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC       pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|PIRNR:PIRNR036370}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_005084503.1; XM_005084446.3.
DR   AlphaFoldDB; A0A1U7QZQ4; -.
DR   STRING; 10036.ENSMAUP00000008494; -.
DR   GeneID; 101833628; -.
DR   KEGG; maua:101833628; -.
DR   CTD; 6768; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   OrthoDB; 5394933at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0060672; P:epithelial cell morphogenesis involved in placental branching; IEA:Ensembl.
DR   GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR   GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00041; CUB; 2.
DR   CDD; cd00112; LDLa; 4.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 4.
DR   Gene3D; 3.30.70.960; SEA domain; 1.
DR   Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR017051; Peptidase_S1A_matripase.
DR   InterPro; IPR000082; SEA_dom.
DR   InterPro; IPR036364; SEA_dom_sf.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR24252:SF8; ACROSIN; 1.
DR   PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR   Pfam; PF00431; CUB; 2.
DR   Pfam; PF00057; Ldl_recept_a; 4.
DR   Pfam; PF01390; SEA; 1.
DR   Pfam; PF00089; Trypsin; 1.
DR   PIRSF; PIRSF036370; ST14; 1.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00042; CUB; 2.
DR   SMART; SM00192; LDLa; 4.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF57424; LDL receptor-like module; 4.
DR   SUPFAM; SSF82671; SEA domain; 1.
DR   SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS01180; CUB; 2.
DR   PROSITE; PS01209; LDLRA_1; 2.
DR   PROSITE; PS50068; LDLRA_2; 4.
DR   PROSITE; PS50024; SEA; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00124};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR036370, ECO:0000256|RuleBase:RU363034};
KW   Membrane {ECO:0000256|PIRNR:PIRNR036370, ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|PIRNR:PIRNR036370, ECO:0000256|RuleBase:RU363034};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Serine protease {ECO:0000256|PIRNR:PIRNR036370,
KW   ECO:0000256|RuleBase:RU363034};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        55..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          86..203
FT                   /note="SEA"
FT                   /evidence="ECO:0000259|PROSITE:PS50024"
FT   DOMAIN          214..334
FT                   /note="CUB"
FT                   /evidence="ECO:0000259|PROSITE:PS01180"
FT   DOMAIN          340..447
FT                   /note="CUB"
FT                   /evidence="ECO:0000259|PROSITE:PS01180"
FT   DOMAIN          615..854
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
FT   ACT_SITE        656
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036370-1"
FT   ACT_SITE        711
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036370-1"
FT   ACT_SITE        805
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036370-1"
FT   DISULFID        459..477
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        471..486
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        496..514
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        508..523
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        525..537
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        532..550
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        544..559
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        567..579
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        587..602
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   855 AA;  94545 MW;  6E1CBFBC71A2D41E CRC64;
     MGSNRGRKAG GSSKDFGARL KYNSGLENMN GFEEGVEFLP VNNAKKVEKR GPRRCVVLVA
     LLVSFLLLSL VAGLLVWHFH YSNVRVQKVF NGHLRVTNEN FLDAYENSNS TEFISLADQV
     KEALKLLYSE VPVLGPYHKR SAVTAFSEGS VIAYYWSEFS IPPHLAEEVD RAMAVERVVT
     LPPRARALKS FVLTSVVAFP TDPRLLGRTQ DNSCSFALHA HGGEVMRFTT PGFPNSPYPA
     HARCQWVLRG DADSVLSLTF RSFDVAPCDE FGSDLVTVYD TLSPMEPHAV VRLCGTYPPS
     YNLTFLSSQN VFLVTLITNT DRRHPGFEAT FFQLPKMTSC GGSLSEAQGL FSSPYFPGHY
     PPNIDCTWNI KVPNNRNVKV RFKLFYLVDP NVPLGTCPKD YVEINGERYC GEKSQFVVSS
     NSSKITVRFH SDHSYTDTGF LAEYLSYDSN DPCPGMFMCN TGRCIQKNLR CDGWADCPDY
     SDERFCRCNT THQFMCKNKL CKPLFWVCDS VNDCGDGSDE EGCSCPAETF KCSNGKCLPQ
     SQKCNGKDNC GDGSDEASCN SVNVVACTKY TYRCQNGLCL NKGNPECDGK TDCSDGSDEK
     NCDCGLRSFT KQARVVGGTN ADEGEWPWQV SLHALGQGHL CGASLISPNW LVSAAHCFMD
     DRNFKYSDHT KWTAFLGLLD QSKRSSTGVQ EHKLKRIITH PLFNEITFDY DIALLELEKP
     AEYSTVVRPI CLPDPTHVFP AGKAIWVTGW GHTQEGGTGA LILQKGEIRV INQTTCEDLM
     PQQITPRMMC VGFLSGGVDS CQGDSGGPLS SVETAGRIFQ AGVVSWGEGC AQRNKPGVYT
     RLPAVRDWIK EQTGV
//
DBGET integrated database retrieval system