GenomeNet

Database: UniProt
Entry: A0A1U7QZW7_MESAU
LinkDB: A0A1U7QZW7_MESAU
Original site: A0A1U7QZW7_MESAU 
ID   A0A1U7QZW7_MESAU        Unreviewed;       317 AA.
AC   A0A1U7QZW7;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   10-APR-2019, entry version 10.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=LOC101843613 {ECO:0000313|RefSeq:XP_005078155.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005078155.1};
RN   [1] {ECO:0000313|RefSeq:XP_005078155.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (DEC-2018) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_005078155.1; XM_005078098.1.
DR   STRING; 10036.XP_005078155.1; -.
DR   GeneID; 101843613; -.
DR   OrthoDB; 1096692at2759; -.
DR   Proteomes; UP000189706; Genome assembly.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000189706};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    317       Hyaluronidase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010567840.
FT   ACT_SITE    135    135       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   DISULFID    211    227       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   317 AA;  36929 MW;  691A5A863E1FF001 CRC64;
     MPSPWGAQLG ELMLFVLVTQ AAIKPAMPPV IKDQPFNIFW AAPTFFCKDH FDVSMNLQAF
     DIIPNPLETK SGTTIAIFYP DELGYYPYFS EDGKSFYGGI PQKGNLSEHL KKSASDIADA
     VTWWRAEGLA VIDWEGWKPQ WDRNWGSREI YKNQSLAFTR HHHPEWSEAK VRTVAQQEFE
     NAGRSFMNIT LTLALEMRPK RLWGFYLYPD CYNYDYRINP EFYTGRCPDD EIFHNDQLLW
     LWEKSTALYS SIYLSKILKS NLNALKFVHF RVREALRVAE MSRKDYALPV FVFSRPFYLQ
     STEALSEVRK NSHIKAG
//
DBGET integrated database retrieval system