ID A0A1U7R041_MESAU Unreviewed; 270 AA.
AC A0A1U7R041;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Left-right determination factor 1 {ECO:0000313|RefSeq:XP_005078287.1};
GN Name=LOC101836049 {ECO:0000313|RefSeq:XP_005078287.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005078287.1};
RN [1] {ECO:0000313|RefSeq:XP_005078287.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_005078287.1; XM_005078230.2.
DR AlphaFoldDB; A0A1U7R041; -.
DR STRING; 10036.ENSMAUP00000007376; -.
DR eggNOG; KOG3900; Eukaryota.
DR OrthoDB; 5391376at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:InterPro.
DR CDD; cd13758; TGF_beta_LEFTY1_2; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR003942; LRDF.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF175; LEFT-RIGHT DETERMINATION FACTOR 2; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PRINTS; PR01427; TGFBETA4.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..270
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010542013"
FT DOMAIN 141..258
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 270 AA; 30383 MW; 46E0968FA4782DAB CRC64;
MWLCWALWAL SLADPGAALT GEQILGSLLQ QLQLSEPPVL DKADVEGLVI PSHVRAQYVS
LLQHSHSGRS RGKRFSQNFR EVAGRFLVSE TSTHLLVFGM EQRLPPNSEL VQAVLRLFQE
PVPRTALRRQ KRLSPHSARA RVTIEWLRFL EDGSNRTALI DSRGTRCCRQ EMYLDLQGMK
WAENWILEPP GFLVYECVGS CLQLPESLTI KWPFLGPRQC VASEMTSLPV IVSMKEGGRT
RPQVVSLPNM RVQTCSCASD GALIPRRLEP
//
