ID A0A1U7R111_MESAU Unreviewed; 506 AA.
AC A0A1U7R111;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Signal peptide peptidase-like 2B isoform X6 {ECO:0000313|RefSeq:XP_005083466.1};
GN Name=Sppl2b {ECO:0000313|RefSeq:XP_005083466.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005083466.1};
RN [1] {ECO:0000313|RefSeq:XP_005083466.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004366}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004366}; Lumenal side
CC {ECO:0000256|ARBA:ARBA00004366}.
CC -!- SIMILARITY: Belongs to the peptidase A22B family.
CC {ECO:0000256|ARBA:ARBA00006859}.
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DR RefSeq; XP_005083466.1; XM_005083409.3.
DR AlphaFoldDB; A0A1U7R111; -.
DR eggNOG; KOG2442; Eukaryota.
DR OrthoDB; 907832at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro.
DR CDD; cd02129; PA_hSPPL_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007369; Peptidase_A22B_SPP.
DR InterPro; IPR006639; Preselin/SPP.
DR PANTHER; PTHR12174; SIGNAL PEPTIDE PEPTIDASE; 1.
DR PANTHER; PTHR12174:SF39; SIGNAL PEPTIDE PEPTIDASE-LIKE 2B; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04258; Peptidase_A22B; 1.
DR SMART; SM00730; PSN; 1.
DR SUPFAM; SSF52025; PA domain; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..506
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010552470"
FT TRANSMEM 168..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 71..146
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
SQ SEQUENCE 506 AA; 56286 MW; 71679D12DD3C5AA1 CRC64;
MAAAARLAAA LLLLAAQVAC EFGVLRVVSQ SGGTRGKDYC ILYNPQWAHL PQDLSKVSLL
KLRDLSSTQL CSHLDLPVED LANQVALVAR GNCTFYEKVR LAQGSGARAL LVVSKEKLVP
PGGNKTQYEE ISIPVALLSH RDLQDIFRRF GHAVMVALYA PSEPVMDYNM VIIFVMAVGT
VALGGYWAGS RDVKKRYMKH KRDDGPEKHE DEAVDVTPVM ICVFVVMCCF MLVLLYYFYD
RLVYVIIGIF CLASSTGLYS CLAPCVRKLP FCTCRVPDNN LPYFHKRPQA RMLLLALFCV
TVTVVWGVFR NEDQWAWVLQ DILGIAFCLY MLRTIRLPTF KACTLLLSVL FIYDVFFVFI
TPFLTKSGNS IMVEVATGPS NSSTHEKLPM VLKVPRLNTS PLSLCDRPFS LLGFGDILVP
GLLVAYCHRF DIQVQSSRIY FVACTIAYGL GLLVTFVALV LMQRGQPALL YLVPCTLMAS
CTVALWRREL GAFWTGSGFV VNTGLL
//