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Database: UniProt
Entry: A0A1U7R111_MESAU
LinkDB: A0A1U7R111_MESAU
Original site: A0A1U7R111_MESAU 
ID   A0A1U7R111_MESAU        Unreviewed;       506 AA.
AC   A0A1U7R111;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Signal peptide peptidase-like 2B isoform X6 {ECO:0000313|RefSeq:XP_005083466.1};
GN   Name=Sppl2b {ECO:0000313|RefSeq:XP_005083466.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005083466.1};
RN   [1] {ECO:0000313|RefSeq:XP_005083466.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004366}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004366}; Lumenal side
CC       {ECO:0000256|ARBA:ARBA00004366}.
CC   -!- SIMILARITY: Belongs to the peptidase A22B family.
CC       {ECO:0000256|ARBA:ARBA00006859}.
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DR   RefSeq; XP_005083466.1; XM_005083409.3.
DR   AlphaFoldDB; A0A1U7R111; -.
DR   eggNOG; KOG2442; Eukaryota.
DR   OrthoDB; 907832at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro.
DR   CDD; cd02129; PA_hSPPL_like; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007369; Peptidase_A22B_SPP.
DR   InterPro; IPR006639; Preselin/SPP.
DR   PANTHER; PTHR12174; SIGNAL PEPTIDE PEPTIDASE; 1.
DR   PANTHER; PTHR12174:SF39; SIGNAL PEPTIDE PEPTIDASE-LIKE 2B; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF04258; Peptidase_A22B; 1.
DR   SMART; SM00730; PSN; 1.
DR   SUPFAM; SSF52025; PA domain; 1.
PE   3: Inferred from homology;
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..506
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010552470"
FT   TRANSMEM        168..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        216..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        243..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        292..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        315..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        439..462
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        468..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          71..146
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
SQ   SEQUENCE   506 AA;  56286 MW;  71679D12DD3C5AA1 CRC64;
     MAAAARLAAA LLLLAAQVAC EFGVLRVVSQ SGGTRGKDYC ILYNPQWAHL PQDLSKVSLL
     KLRDLSSTQL CSHLDLPVED LANQVALVAR GNCTFYEKVR LAQGSGARAL LVVSKEKLVP
     PGGNKTQYEE ISIPVALLSH RDLQDIFRRF GHAVMVALYA PSEPVMDYNM VIIFVMAVGT
     VALGGYWAGS RDVKKRYMKH KRDDGPEKHE DEAVDVTPVM ICVFVVMCCF MLVLLYYFYD
     RLVYVIIGIF CLASSTGLYS CLAPCVRKLP FCTCRVPDNN LPYFHKRPQA RMLLLALFCV
     TVTVVWGVFR NEDQWAWVLQ DILGIAFCLY MLRTIRLPTF KACTLLLSVL FIYDVFFVFI
     TPFLTKSGNS IMVEVATGPS NSSTHEKLPM VLKVPRLNTS PLSLCDRPFS LLGFGDILVP
     GLLVAYCHRF DIQVQSSRIY FVACTIAYGL GLLVTFVALV LMQRGQPALL YLVPCTLMAS
     CTVALWRREL GAFWTGSGFV VNTGLL
//
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