ID A0A1U7R2I7_MESAU Unreviewed; 1516 AA.
AC A0A1U7R2I7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Protein dispatched homolog 1 isoform X2 {ECO:0000313|RefSeq:XP_005078173.1, ECO:0000313|RefSeq:XP_021087506.1};
GN Name=Disp1 {ECO:0000313|RefSeq:XP_005078173.1,
GN ECO:0000313|RefSeq:XP_021087506.1, ECO:0000313|RefSeq:XP_021087507.1,
GN ECO:0000313|RefSeq:XP_021087508.1, ECO:0000313|RefSeq:XP_021087509.1,
GN ECO:0000313|RefSeq:XP_021087510.1, ECO:0000313|RefSeq:XP_021087512.1,
GN ECO:0000313|RefSeq:XP_021087513.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005078173.1};
RN [1] {ECO:0000313|RefSeq:XP_005078173.1, ECO:0000313|RefSeq:XP_021087506.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the dispatched family.
CC {ECO:0000256|ARBA:ARBA00038046}.
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DR RefSeq; XP_005078173.1; XM_005078116.3.
DR RefSeq; XP_021087506.1; XM_021231847.1.
DR RefSeq; XP_021087507.1; XM_021231848.1.
DR RefSeq; XP_021087508.1; XM_021231849.1.
DR RefSeq; XP_021087509.1; XM_021231850.1.
DR RefSeq; XP_021087510.1; XM_021231851.1.
DR RefSeq; XP_021087512.1; XM_021231853.1.
DR RefSeq; XP_021087513.1; XM_021231854.1.
DR STRING; 10036.ENSMAUP00000011101; -.
DR eggNOG; KOG3664; Eukaryota.
DR OrthoDB; 2875706at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1904680; F:peptide transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0060539; P:diaphragm development; IEA:Ensembl.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
DR GO; GO:0009880; P:embryonic pattern specification; IEA:Ensembl.
DR GO; GO:0007225; P:patched ligand maturation; IEA:Ensembl.
DR GO; GO:0015833; P:peptide transport; IEA:Ensembl.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45951:SF4; PROTEIN DISPATCHED HOMOLOG 1; 1.
DR PANTHER; PTHR45951; PROTEIN DISPATCHED-RELATED; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 183..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 592..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 713..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 979..998
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1004..1026
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1073..1090
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1102..1121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 519..653
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 15..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1347..1442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1516 AA; 169086 MW; A584224246216425 CRC64;
MAVISGSDSV LLSNGSISTS TTNPCPLTPS DGDQLTPREA PRTKASPNGC LHLNGTVKSS
FLPLDNQRTP QMPAQCCRPC PYHHPVTSHN HHQECHSEAG PTASSALASC CMQPHPEYSA
SLCPNHSPVY QAAHCLQPSP SFCLHHPWPD HFQHQPVQQH LAIIRPSRPF KFPRSYAALL
ADWPVVVLGM CTLLIVVCAL VGVLVPELPD FSDPLLGFEP RGTAIGQRLV TWNNMMKNTG
YKATLANYPY KYAEEQAKSH RDDRWSDDHH ERERRDVDWN FQKDSFFCDV PSDGYSRVVF
ASAGGETLWN LPAIKSMCDV DNSRIRSHPQ FSDLCQRTTA VSCCPSWTLG NYIAILNNRS
SCQKIVERDV SHTLKLLRTC AKHYQNGTLG PDCWDKAARR KDQLKCTSVP RKCTKYNAVY
QILHYLVDKD FLAPKTADYA VPALKYSMLF SPTEKGESMM NIYLDNFENW NSSDGITTVT
GIEFGIKHSL FQGYLLMDTV YPAIAIVIVL LIMCVYTKSM FITLMTMFAI ISSLIVSYFL
YRVVFNFEFF PFMNLTALII LVGIGADDAF VLCDVWNYTK FDKPRAETSE AVSITLQHAA
LSMFVTSFTT AAAFYANYVS NITAIRCFGV YAGTAILVNY VLMVTWLPAV IVLHERYLLN
IFSCFRKPQP QAYDKSCWAV LCQKCRKVLF AISEASRIFF EKVLPCIVIK FRYLWLIWFL
ALTIGGAYIV CINPKMKLPS LELSEFQVFR SSHPFERYDA EFKKLFMFER VHHGEELHMP
ITVIWGVSPE DSGNPLNPKS KGKLTLDSTF NIASPASQAW ILHFCQKLRN QTFFHQTDQQ
DFTSCFIETF KQWMENQDCD EPALYPCCSH CSFPYKQEVF ELCIKKAIME LDRSTGYHLN
NKTPGPRFDI NDTIRAVVLE FQSTFLFTLA YEKMQQFYKE VDSWISSELS SAPEGLSHGW
FVSNLEFYDL QDSLSDGTLI AMGLSVAVAF SVMLLTTWNV IISLYAIISI AGTIFVTVGS
LVLLGWELNV LESVTISVAV GLSVDFAVHY GVAYRLAPDP DREGKVIFSL SRMGSAIAMA
ALTTFVAGAM MMPSTVLAYT QLGTFMMLVM CVSWAFATFF FQCMCRCLGP QGTCGQIPLP
KKLQCSAFSH TLPASPGDRG PSKTHTAGAY RVDARGPNSE LEHEFYELQP LASPGCTASE
KNTYEEPHIC SEFFNGQAKT LGLPVPATYN SELAKSPRNE PGPALLQPCL EQGATCHFSL
NQRCSCPDAY AHLEYGPHSC PRMGHPSCPR CAAIASSFVQ IPNAVAPPKA THQAAEVLMH
PTRHMLPPGM QSSLPRNCFL HPVQRMQPQE QLDDSSIQSL QGMDEHPPGT AEPLLPVGRS
PESFQRACCH PENNQRGLCK SRDTGDTEVS GGTETKVSSL PNQTDKAEKK VEPSQPQTDE
NVNSEHLNHN EAQFMFSHLL GEADCRSCPG SPHSCRHIVR LKRGSTDCPM PNLEANVPAV
PTHSELSGES LLIKTL
//
