ID A0A1U7R3N5_MESAU Unreviewed; 632 AA.
AC A0A1U7R3N5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Nuclear receptor subfamily 4 group A member 3 {ECO:0000313|RefSeq:XP_005078780.1};
GN Name=Nr4a3 {ECO:0000313|RefSeq:XP_005078780.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005078780.1};
RN [1] {ECO:0000313|RefSeq:XP_005078780.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR4
CC subfamily. {ECO:0000256|ARBA:ARBA00006423}.
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DR RefSeq; XP_005078780.1; XM_005078723.3.
DR AlphaFoldDB; A0A1U7R3N5; -.
DR STRING; 10036.ENSMAUP00000008734; -.
DR GeneID; 101838247; -.
DR KEGG; maua:101838247; -.
DR CTD; 8013; -.
DR eggNOG; KOG4217; Eukaryota.
DR OrthoDB; 5395768at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0010828; P:positive regulation of glucose transmembrane transport; IEA:Ensembl.
DR GO; GO:1900625; P:positive regulation of monocyte aggregation; IEA:Ensembl.
DR GO; GO:1904754; P:positive regulation of vascular associated smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:1904707; P:positive regulation of vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR CDD; cd06969; NR_DBD_NGFI-B; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR003070; NR4A1-3.
DR InterPro; IPR003072; NR4A3.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24085; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24085:SF2; NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 3; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01286; NORNUCRECPTR.
DR PRINTS; PR01284; NUCLEARECPTR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 295..370
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 400..629
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 96..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..114
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 68986 MW; BB8D857A8A44B888 CRC64;
MPCVQAQYSP SPPGSTYATQ TYGSEYTTEI MNPDYAKLTM DLGSTGIMAT ATTSLPSFST
FMEGYPSSCE LKPSCLYQMP PSGPRPLIKM EEGREHGYHH HHHHHHHHHH HHQQQQQQPS
IPPPSGPEDD VVPSTSMYFK QSPPSTPSTP GFPPQAGALW DEELPSAPGC IAPGQLLDPQ
MKAVPPMAAA RFPPIFHFKP SPPHPPAPSP AGGHHLGYDP AAAAALSLPL GAAAAAGSQA
SALEGHPYGL PLSKRTTAAL TFPPLGLTAS PTASSLLGES PSLPSPPNRS SSSGEGTCAV
CGDNAACQHY GVRTCEGCKG FFKRTVQKNA KYVCLANKNC PVDKRRRNRC QYCRFQKCLS
VGMVKEVVRT DSLKGRRGRL PSKPKSPLQQ EPSQPSPPSP PICMMNALVR ALTDATPRDL
DYSRYCPTDQ ATAGTDAEHV QQFYNLLTAS IDVSRSWAEK IPGFTDLPKE DQTLLIESAF
LELFVLRLSI RSNAAEDKFV FCSGLVLHRL QCLRGFGEWL DSIKDFSLSL QSLNLDIQAL
ACLSALSMIT ERHGLKEPKR VEELCNRITS SLKDHQRKGQ APEPSEPKVL RALVELRKIC
TQGLQRIFYL KLEDLVAPPS IIDKLFLDTL PF
//
