ID   A0A1U7R4B3_MESAU        Unreviewed;       849 AA.
AC   A0A1U7R4B3;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Ras GTPase-activating protein 2 {ECO:0000313|RefSeq:XP_005080785.1};
GN   Name=Rasa2 {ECO:0000313|RefSeq:XP_005080785.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005080785.1};
RN   [1] {ECO:0000313|RefSeq:XP_005080785.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_005080785.1; XM_005080728.3.
DR   AlphaFoldDB; A0A1U7R4B3; -.
DR   STRING; 10036.ENSMAUP00000004802; -.
DR   GeneID; 101831785; -.
DR   KEGG; maua:101831785; -.
DR   CTD; 5922; -.
DR   eggNOG; KOG2059; Eukaryota.
DR   OrthoDB; 24454at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR   CDD; cd08401; C2A_RasA2_RasA3; 1.
DR   CDD; cd04010; C2B_RasA3; 1.
DR   CDD; cd13370; PH_GAP1m_mammal-like; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR037773; RASA2_PH.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001562; Znf_Btk_motif.
DR   PANTHER; PTHR10194:SF21; RAS GTPASE-ACTIVATING PROTEIN 2; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF00779; BTK; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   PRINTS; PR00402; TECBTKDOMAIN.
DR   SMART; SM00107; BTK; 1.
DR   SMART; SM00239; C2; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR   PROSITE; PS51113; ZF_BTK; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00432}.
FT   DOMAIN          21..139
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          150..290
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          357..551
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   DOMAIN          605..706
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          824..849
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   849 AA;  96975 MW;  2B9E6B0781E71BD0 CRC64;
     MAAAAAPAAA AASPEAPAVT GKAEPEAGDE DSREVRVLQS LRGRIYEAKN LLPYLGPNKM
     RDCFCTINLD QEEVYRTQVV EKSLRPYFSE EFYFEIPRTF QYLSFYVYDK NVLQRDLRIG
     KVAIKKEDLC NHSGKETWFS LQPIDSNSEV QGKVHLELKL NELITENGTV CQQLVVHIKA
     CHGLPLINGQ NCDPYATVSL VGPSRNDQKK TKVKKKTSNP QFNEIFYFEV TRSSSYTRKS
     QFQVEEEDIE KLEIRIDLWN NENLVQDVFL GEIKVPVNVL RNDSSHQAWY LLQPRDNGNK
     SSKTDDLGSL RLTLCYTEDY VLPSEYYDPL KTLLLKSPDV QPVSASAAYI LGEICQDQKD
     AVLPLVRLLL QHNKLVPFIT AVAELDLKDT QDASTIFRGN TLATRCLDEM MKIVGGHYLK
     VTLKPILDEI CESSKSCEID PVKLKEGDNV ENNKENLHYY VDKVFNTIVG SSVSCPTVMC
     DIFYSLRQMA AKRFPNNPHV QYSAVTSFVF LRFFAVAILS PHTFHLRPHY PDTQTNRTLT
     LISKTIQTLG NWGSLSRRKS RSKKSVMCEF LKMFQEERYF TDVKKFLDEI SSTETKESSG
     TSEPVHLKEG EMYKRAQGRT RIGKKNFKKR WFCLTSRELT YHKQPGKDAI YTIPVKNILA
     VEKLEESSFN KKNMFQVIHT EKTLYVQANN CVEANEWIDK LCRVSRCNHN RLSSFHPSAY
     LNGNWLCCQE TSENTPGCKP CTAGIPADIQ IDIDEDRETE RIYSLFTLSL PKLQKMEEAC
     GTIAVYQGPQ KEPDYCNFTI EDSVTTFKTI QQIKSIIEKL DEPHEKYRKK RSSSAKYGSK
     ENPIVGKIS
//