ID A0A1U7R5X5_MESAU Unreviewed; 744 AA.
AC A0A1U7R5X5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Inactive tyrosine-protein kinase transmembrane receptor ROR1 {ECO:0000313|RefSeq:XP_005086697.2};
GN Name=Ror1 {ECO:0000313|RefSeq:XP_005086697.2};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005086697.2};
RN [1] {ECO:0000313|RefSeq:XP_005086697.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28071753;
RA McCann K.E., Sinkiewicz D.M., Norvelle A., Huhman K.L.;
RT "De novo assembly, annotation, and characterization of the whole brain
RT transcriptome of male and female Syrian hamsters.";
RL Sci. Rep. 7:40472-40472(2017).
RN [2] {ECO:0000313|RefSeq:XP_005086697.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR RefSeq; XP_005086697.2; XM_005086640.2.
DR AlphaFoldDB; A0A1U7R5X5; -.
DR eggNOG; KOG1026; Eukaryota.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00108; KR; 1.
DR CDD; cd05090; PTKc_Ror1; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR24416:SF134; INACTIVE TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR1; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF00051; Kringle; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00018; KRINGLE.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00130; KR; 1.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS00021; KRINGLE_1; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Kinase {ECO:0000313|RefSeq:XP_005086697.2};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Receptor {ECO:0000313|RefSeq:XP_005086697.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transferase {ECO:0000313|RefSeq:XP_005086697.2};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|RefSeq:XP_005086697.2};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 211..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..106
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 119..198
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 280..553
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 560..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 744 AA; 82828 MW; D71C9DCF01ABFD83 CRC64;
MQGEIENQIT AAFTMIGTSS HLSDKCSQFA IPSLCHYAFP YCDETSSVPK PRDLCRDECE
VLENVLCQTE YIFARSNPMI LMRLKLPNCE DLPQPESPEA ANCIRIGIPM ADPINKNHKC
YNSTGVDYRG TVSVTKSGRQ CQPWNSQYPH THSFTALRFP ELNGGHSYCR NPGNQKEAPW
CFTLDENFKS DLCDIPACDS KDSKEKNKME ILYILVPSVA IPLAIAFLFF FICVCRNNQK
SSSPPVQRQP KPVRGQNVEM SMLNAYKPKS KAKELPLSAV RFMEELGECT FGKIYKGHLY
LPGMDHAQLV AIKTLKDYNN PQQWTEFQQE ASLMAELHHP NIVCLLGAVT QEQPVCMLFE
YTNQGDLHEF LIMRSPHSDV GCSSDEDGTV KSSLDHGDFL HIAIQIAAGM EYLSSHFFVH
KDLAARNILI GEQLHVKISD LGLSREIYSA DYYRVQSKSS LPIRWMPPEA IMYGKFSSDS
DIWSFGVVLW EIFSFGLQPY YGFSNQEVIE MVRKRQLLPC SEDCPPRMYS LMTECWNEIP
SRRPRFKDIH VRLRSWEGLS SHTSSTTPSG GNATTQTTSL SASPVSNLSN PRFPNYMFPG
QGITPQGQIA GFIGPAIPQN QRFIPINGYP IPPGYAAFPA AHYQPAGPPR VIQHCPPPKS
RSPSSASGST STGHVASLPS SGSNQEANVP LLPHMSIPNH PGGMGITVFG NKSQKPYKID
SKQPSLLGDS NIHGHTESMI SAEV
//
