ID A0A1U7R851_MESAU Unreviewed; 742 AA.
AC A0A1U7R851;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Collectin-12 {ECO:0000256|ARBA:ARBA00017460};
GN Name=Colec12 {ECO:0000313|RefSeq:XP_005083088.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005083088.1};
RN [1] {ECO:0000313|RefSeq:XP_005083088.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005083088.1; XM_005083031.3.
DR AlphaFoldDB; A0A1U7R851; -.
DR STRING; 10036.ENSMAUP00000007188; -.
DR GeneID; 101841924; -.
DR KEGG; maua:101841924; -.
DR CTD; 81035; -.
DR eggNOG; ENOG502QQKQ; Eukaryota.
DR OrthoDB; 4613106at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0030169; F:low-density lipoprotein particle binding; IEA:Ensembl.
DR GO; GO:0038187; F:pattern recognition receptor activity; IEA:Ensembl.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:Ensembl.
DR GO; GO:0071360; P:cellular response to exogenous dsRNA; IEA:Ensembl.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:Ensembl.
DR GO; GO:0006910; P:phagocytosis, recognition; IEA:Ensembl.
DR GO; GO:0044857; P:plasma membrane raft organization; IEA:Ensembl.
DR GO; GO:0034138; P:toll-like receptor 3 signaling pathway; IEA:Ensembl.
DR CDD; cd03590; CLECT_DC-SIGN_like; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR033989; CD209-like_CTLD.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR22803:SF146; COLLECTIN-12; 1.
DR PANTHER; PTHR22803; MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED; 1.
DR Pfam; PF01391; Collagen; 3.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lectin {ECO:0000256|ARBA:ARBA00022734}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 614..731
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT REGION 439..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 76..128
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 220..254
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 519..539
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..587
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 742 AA; 81507 MW; 93F39EF5CC72E2AE CRC64;
MKDDFAEEEE VQSFGYKRFG IQEGTQCTKC KNNWALKFSI ILLYILCALL TITVAILGYK
VVEKMDNVTG GMETSRQTYN DKLTAVESDL KKLGDQTGKK AISTNSELST FRSDILDLRQ
QLQEITEKTS KNKDTLEKLQ ASGDSLVDRQ SQLKETLQNN SFLITTVNKT LQAYNGYVTN
LQQDTSVLQG NLQNQMYSQN MVIMNLNNLN LTQVQQRNLI TNLQRSVDDT SQAIQRIKND
FQNLQQVFLQ AKKDTDWLKE KVQSLQTLAA NNSALAKANN DTLEDMNSQL SSFTGQMDNI
TTLSQANEQS LKDLQDLHKD AENRTAIKFS QLEERFQVFE TDIVNIISNI SYTAHHLRTL
TSNLNEVRTT CTDTLTRHTD DLTSLNNTLV NIRLDSVSLR MQQDMMRSRL DTEVANLSVI
MEEMKLVDSK HGQLIKNFTI LQGPPGPRGP KGDRGSQGPP GPTGNKGQKG EKGEPGPPGP
AGERGPIGPA GPPGERGNKG SKGSQGPKGS RGSPGKPGPQ GPNGDPGPPG PPGKDGLPGP
QGPPGFQGLQ GTVGEPGVPG PRGLPGLPGV PGMPGPKGPP GPPGPSGAME PLALQNEPTP
ASETNGCPPR WKNFTDKCYY FSVEKEIFED AKLFCEDKSS HLVFINSREE QQWIKKQTVG
KDSHWIGLTD SEHENEWKWL DGTPVDYKNW KAGQPDNWGS SHGPGEDCAG LIYAGQWNDF
QCDEINNFIC EKEREAVPSP TL
//
