ID A0A1U7R8S4_ALLSI Unreviewed; 538 AA.
AC A0A1U7R8S4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Tyrosine-protein kinase {ECO:0000256|RuleBase:RU362096};
DE EC=2.7.10.2 {ECO:0000256|RuleBase:RU362096};
GN Name=FGR {ECO:0000313|RefSeq:XP_006019288.1,
GN ECO:0000313|RefSeq:XP_006019289.1, ECO:0000313|RefSeq:XP_006019290.1,
GN ECO:0000313|RefSeq:XP_025054491.1, ECO:0000313|RefSeq:XP_025054492.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|RefSeq:XP_006019288.1};
RN [1] {ECO:0000313|RefSeq:XP_006019288.1, ECO:0000313|RefSeq:XP_006019290.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001149,
CC ECO:0000256|RuleBase:RU362096};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. {ECO:0000256|RuleBase:RU362096}.
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DR RefSeq; XP_006019288.1; XM_006019226.3.
DR RefSeq; XP_006019289.1; XM_006019227.3.
DR RefSeq; XP_006019290.1; XM_006019228.3.
DR RefSeq; XP_025054491.1; XM_025198706.1.
DR RefSeq; XP_025054492.1; XM_025198707.1.
DR STRING; 38654.A0A1U7R8S4; -.
DR GeneID; 102369028; -.
DR KEGG; asn:102369028; -.
DR CTD; 2268; -.
DR eggNOG; KOG0197; Eukaryota.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14203; PTKc_Src_Fyn_like; 1.
DR CDD; cd10418; SH2_Src_Fyn_isoform_a_like; 1.
DR CDD; cd12006; SH3_Fyn_Yrk; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR047924; Fyn/Yrk_SH2.
DR InterPro; IPR035750; Fyn/Yrk_SH3.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR24418:SF224; TYROSINE-PROTEIN KINASE FGR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141,
KW ECO:0000256|RuleBase:RU362096};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362096};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023139};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362096};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW ECO:0000256|RuleBase:RU362096}.
FT DOMAIN 83..144
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 150..247
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 272..525
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 300
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 538 AA; 60227 MW; 2D8961FE1A851D35 CRC64;
MGCVQCKKKG SGKAQGEGCD GKLSLVPSTH YDPDPTQPAA SFSCIPDFNN FHGSPTPAGT
AFLGPGLYPS NTLHGRGGGI TGGGVTLFIA LYDYEARTED DLTFLKGEKF HIINNTEGDW
WEARSLSTGA TGYVPSNYVA PVDSIQAEEW YFGKIGRKDA ERQILCPGNP RGTFLIRESE
TTKGAYSLSI RDWDEAKGDH VKHYKIRKLD NGGYYITTRA QFETVQQLVQ HYIERAAGLC
CRLVVPCHRG MPKLADLSVK TKDVWEIPRE SLQLLKKLGN GQFGEVWMGT WNGTTKVAVK
TLKPGTMSPE AFLEEAQIMK RLRHDKLVQL YAVVSEEPIY IVTEFMSQGS LLDFLKDGDG
RFLKLPQLVD MAAQIAAGMA YIERMNYIHR DLRAANILVG DNLVCKIADF GLARLIEDDE
YTARQGAKFP IKWTAPEAAL FGRFTIKSDV WSFGILLTEL VTKGRVPYPG MNNREVLEQV
ERGYRMQCPG SCPSSLHELM VQCWKKEPEE RPTFEYLQSF LEDYFTATEP QYQPGDDQ
//
