ID A0A1U7R9R8_MESAU Unreviewed; 226 AA.
AC A0A1U7R9R8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Lysoplasmalogenase TMEM86B {ECO:0000256|ARBA:ARBA00039876};
DE EC=3.3.2.2 {ECO:0000256|ARBA:ARBA00035673};
DE AltName: Full=Transmembrane protein 86B {ECO:0000256|ARBA:ARBA00042674};
GN Name=Tmem86b {ECO:0000313|RefSeq:XP_005084184.1,
GN ECO:0000313|RefSeq:XP_021091022.1, ECO:0000313|RefSeq:XP_021091023.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|RefSeq:XP_005084184.1};
RN [1] {ECO:0000313|RefSeq:XP_005084184.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- FUNCTION: Catalyzes the hydrolysis of the vinyl ether bond of choline
CC or ethanolamine lysoplasmalogens, forming fatty aldehyde and
CC glycerophosphocholine or glycerophosphoethanolamine, respectively and
CC is specific for the sn-2-deacylated (lyso) form of plasmalogen.
CC {ECO:0000256|ARBA:ARBA00037660}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-
CC saturated aldehyde + sn-glycerol 3-phosphocholine;
CC Xref=Rhea:RHEA:22544, ChEBI:CHEBI:15377, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:73359, ChEBI:CHEBI:77287; EC=3.3.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00035598};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a
CC 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine;
CC Xref=Rhea:RHEA:16905, ChEBI:CHEBI:15377, ChEBI:CHEBI:73359,
CC ChEBI:CHEBI:77288, ChEBI:CHEBI:143890; EC=3.3.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00035579};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM86 family.
CC {ECO:0000256|ARBA:ARBA00007375}.
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DR RefSeq; XP_005084184.1; XM_005084127.3.
DR RefSeq; XP_021091022.1; XM_021235363.1.
DR RefSeq; XP_021091023.1; XM_021235364.1.
DR STRING; 10036.ENSMAUP00000001952; -.
DR GeneID; 101829923; -.
DR KEGG; maua:101829923; -.
DR CTD; 255043; -.
DR eggNOG; KOG4804; Eukaryota.
DR OrthoDB; 3030862at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0047408; F:alkenylglycerophosphocholine hydrolase activity; IEA:Ensembl.
DR GO; GO:0047409; F:alkenylglycerophosphoethanolamine hydrolase activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046485; P:ether lipid metabolic process; IEA:Ensembl.
DR InterPro; IPR012506; TMEM86B-like.
DR PANTHER; PTHR31885; GH04784P; 1.
DR PANTHER; PTHR31885:SF7; LYSOPLASMALOGENASE; 1.
DR Pfam; PF07947; YhhN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 226 AA; 24726 MW; 5EAD37D49421CFF9 CRC64;
MDPGKEGLLL KILFSDQHPQ VRRWLIPFFV SCVVYFVLWI PEDQPSWFSA LVKCLPILCL
VVFLWAVTPG GSYPWLLQGG LVCSAVGDAC LIWPGAFLYG MAAFFATHVL YVWAFGLSPL
RPGVLASVIP CALVYGSFLL PHLESGMVLP VSAYGLILFS MLWRSLARGG SAAWGGTLFT
ISDSVLAWNA FIQPLGFARQ VTMTTYYAAQ LCLALSALRN PGLKTN
//
