ID A0A1U7RAL4_MESAU Unreviewed; 351 AA.
AC A0A1U7RAL4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Sodium/potassium-transporting ATPase subunit beta {ECO:0000256|RuleBase:RU362099};
GN Name=Atp1b4 {ECO:0000313|RefSeq:XP_005083167.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005083167.1};
RN [1] {ECO:0000313|RefSeq:XP_005083167.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May act as a transcriptional coregulator during muscle
CC development through its interaction with SNW1. Has lost its ancestral
CC function as a Na,K-ATPase beta-subunit.
CC {ECO:0000256|ARBA:ARBA00037398}.
CC -!- FUNCTION: This is the non-catalytic component of the active enzyme,
CC which catalyzes the hydrolysis of ATP coupled with the exchange of
CC Na(+) and K(+) ions across the plasma membrane.
CC {ECO:0000256|RuleBase:RU362099}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}. Nucleus
CC inner membrane {ECO:0000256|ARBA:ARBA00037816}; Single-pass type II
CC membrane protein {ECO:0000256|ARBA:ARBA00037816}.
CC -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC {ECO:0000256|ARBA:ARBA00005876, ECO:0000256|RuleBase:RU362099}.
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DR RefSeq; XP_005083167.1; XM_005083110.2.
DR AlphaFoldDB; A0A1U7RAL4; -.
DR GeneID; 101844422; -.
DR KEGG; maua:101844422; -.
DR CTD; 23439; -.
DR OrthoDB; 2880589at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR Gene3D; 2.60.40.1660; Na, k-atpase alpha subunit; 1.
DR InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR NCBIfam; TIGR01107; Na_K_ATPase_bet; 1.
DR PANTHER; PTHR11523:SF12; PROTEIN ATP1B4; 1.
DR PANTHER; PTHR11523; SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT; 1.
DR Pfam; PF00287; Na_K-ATPase; 1.
DR PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
DR PROSITE; PS00391; ATPASE_NA_K_BETA_2; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|RuleBase:RU362099};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362099};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362099};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362099}; Transport {ECO:0000256|RuleBase:RU362099}.
FT TRANSMEM 105..129
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362099"
FT REGION 35..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..70
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 351 AA; 40731 MW; 61EC083B12E5151F CRC64;
MRRQLRSRRA PAFPYGYRYR LDDQDEVNQN YLADEEEEAE EEAQVMTVPG LEEEEEEEEG
KEEEEEREEE GQGQPTGNAW RRKLQIVTEY LWDPEKRMSL ARTGLILVIY FFFYASLAAV
ITLFLYMLFL TISPYMPTFT EQVKPPGVMI RPFAHSLNFN FNVSEPETWQ HYVISLNGFL
QGYNDSLQEE MNVDCPPGQY FIQDGDEDED KKACQFKRSF LKNCSGLEDP TFGYSTGQPC
ILLKMNRIVG FRPELGDPVK VSCKVQKGDE NDIRSINYYP ESASFDLRYY PYYGKLTHVN
YTSPLVAMHF TDVVKNQAVP VQCQLKGKGI INDVINDRFV GRIVFTLNIE T
//
