ID A0A1U7RCR3_ALLSI Unreviewed; 1215 AA.
AC A0A1U7RCR3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Zinc finger E-box-binding homeobox 2 isoform X1 {ECO:0000313|RefSeq:XP_025057038.1, ECO:0000313|RefSeq:XP_025057039.1};
GN Name=ZEB2 {ECO:0000313|RefSeq:XP_025057038.1,
GN ECO:0000313|RefSeq:XP_025057039.1, ECO:0000313|RefSeq:XP_025057040.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025057040.1};
RN [1] {ECO:0000313|RefSeq:XP_025057038.1, ECO:0000313|RefSeq:XP_025057039.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger
CC family. {ECO:0000256|ARBA:ARBA00009867}.
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DR RefSeq; XP_006021383.1; XM_006021321.2.
DR RefSeq; XP_006021384.1; XM_006021322.2.
DR RefSeq; XP_014374315.1; XM_014518829.1.
DR RefSeq; XP_025057038.1; XM_025201253.1.
DR RefSeq; XP_025057039.1; XM_025201254.1.
DR RefSeq; XP_025057040.1; XM_025201255.1.
DR STRING; 38654.A0A1U7RCR3; -.
DR eggNOG; KOG3623; Eukaryota.
DR OrthoDB; 4266655at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:UniProt.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR008598; Di19_Zn-bd.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24391; HISTONE H4 TRANSCRIPTION FACTOR-RELATED; 1.
DR PANTHER; PTHR24391:SF18; ZINC FINGER PROTEIN 1; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF05605; zf-Di19; 1.
DR Pfam; PF12874; zf-met; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125,
KW ECO:0000313|RefSeq:XP_025057038.1};
KW Homeobox {ECO:0000313|RefSeq:XP_025057038.1,
KW ECO:0000313|RefSeq:XP_025057039.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 211..239
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 241..263
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 282..309
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1000..1027
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1028..1055
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1056..1084
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1118..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1126..1156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1157..1172
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1173..1215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1215 AA; 136331 MW; C7DF6AEF01DA5C6D CRC64;
MKQQIMADGP RCKRRKQPNP RRKNVLNYEN VVETGSETDE EDKLHIAEDD SIINTLDQET
SPASVPNHES SPHVSQAVLP REEEEDEMRE SGVDHTWHNS EILQASVNGP EEMKEEYDTM
GPEATIQTTG NNGTVKNANC TSDFEEYFAK RKLEEGDGHA VSIAEYLQRS DTAIIYPEAP
EELSRLGTPE ANGQEENDLP PGTPDAFAQL LTCPYCDRGY KRLTSLKEHI KYRHEKNEEN
FSCPLCSYTF AYRTQLERHM VTHKPGTDQH QMLTQGAGNR KFKCTECGKA FKYKHHLKEH
LRIHSGEKPY ECPNCKKRFS HSGSYSSHIS SKKCIGLISV NGRMRNNIKT GSSPNSVSSS
PTNSAITQLR NKLENGKPLS MSEQTGLLKI KTEPLDFNEY KVLMASHGFS GASPFMNGGL
GATSPLGVHA SAQSPMQHLG VGMEAPLLGF PAVGSNLSEV QKVLQIVDNT VSRQKMDCKA
EEISKLKGYH MKDSCPQAEE QGVTSPGIPP VGLPVVSHNG ATKSIIDYTL EKVNEAKACL
QSLTTDSRRQ LNNIKKEKLR TLIDLVTEDK MIENHNVSTP FSCQFCKESF PGPIPLHQHE
RYLCKMNEEI KAVLQPHENM VPNKPGVFVD KQALLLSSVL SEKGMTSPIN PYKDHMSVLK
AYYAMNMEPN SDELLKISIA VGLPQEFVKE WFEQRKVYQY SSSRSPSLER TSAKVALAAT
NNTPTKDSLS ARSPIKPVDS ITSPSIAELH NSVTNCDTPL RLTKPPHFTN IKPVDKLDHS
RSNTPSPLNL SSTSSKNSHS SSYTPNSFSS EELQAEPLDL SLPKQMKEPK SIIATKNKTK
SSSVNLDHNS VSSSSENSDE PLNLTFIKKE FSNSNNLDKS TNPVFSMNPF SAKPLYTTLP
PQSAFPPATF MPPVQTSIPG LRPYPGLDQM SFLPHMAYTY PTGAATFADM QQRRKYQRKQ
GFQGELLDGT PDYMSGLDDM TDSDSCLSRK KIKKTESGMY ACDLCDKTFQ KSSSLLRHKY
EHTGKRPHQC QICKKAFKHK HHLIEHSRLH SGEKPYQCDK CGKRFSHSGS YSQHMNHRYS
YCKREAEERE AAEREAREKG HLEPTELLMN RAYLQSITPQ GYSDSEERES MPRDGESEKE
HEKEGEDGYE KLGRQDGDEE FEEEEEESEN KSMDTDPDTI RDEEETGDHS MDDSSEDGKM
ETKSDHEEDN MEDGM
//
