ID A0A1U7RDM2_MESAU Unreviewed; 358 AA.
AC A0A1U7RDM2;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Protein shisa-9 {ECO:0000313|RefSeq:XP_005086557.2};
GN Name=LOC101824657 {ECO:0000313|RefSeq:XP_005086557.2};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005086557.2};
RN [1] {ECO:0000313|RefSeq:XP_005086557.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Regulator of short-term neuronal synaptic plasticity in the
CC dentate gyrus. Associates with AMPA receptors (ionotropic glutamate
CC receptors) in synaptic spines and promotes AMPA receptor
CC desensitization at excitatory synapses.
CC {ECO:0000256|ARBA:ARBA00037492}.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendritic spine membrane
CC {ECO:0000256|ARBA:ARBA00029429}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00029429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the shisa family. SHISA9 subfamily.
CC {ECO:0000256|ARBA:ARBA00038448}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005086557.2; XM_005086500.3.
DR AlphaFoldDB; A0A1U7RDM2; -.
DR eggNOG; ENOG502QT2A; Eukaryota.
DR OrthoDB; 5350575at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0032591; C:dendritic spine membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31774:SF1; PROTEIN SHISA-9; 1.
DR PANTHER; PTHR31774; PROTEIN SHISA-9-RELATED; 1.
DR Pfam; PF13908; Shisa; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 193..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 358 AA; 38666 MW; 00C522BB0D70AA16 CRC64;
MCGQRRPAAP ASSLGSFGRA SRGGGSDSSG GRALLPSLGD TMRRVLRLLL GCFLTELCAR
VCRAQERAGH GQLAQLGGVL LLTGGNRSGA ASGEAGEGVG GSDAPPTRAP TPDSCRGYFD
VMGQWDPPFN CSSGDFIFCC GTCGFRFCCT FKKRRLNQST CTNYDTPLWL NTGKPPARKD
DPLHDPTKDK TNLIVYIICG VVAVMVLVGI FTKLGLEKAH RPQREHMSRA LADVMRPQGH
CNTDHMERDL NIVVHVQHYE NMDTRTPINN LHTTQMNNAV PTSPLLQQMG HPHSYPNLGQ
ISNPYEQQPP GKELNKYASL KAVGNSDGDW AVATLKSPKG TVLLLLTLCP GVVKLNIE
//
