ID A0A1U7RG68_MESAU Unreviewed; 538 AA.
AC A0A1U7RG68;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Lysosomal cobalamin transport escort protein LMBD1 {ECO:0000256|ARBA:ARBA00039618};
DE AltName: Full=LMBR1 domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042599};
GN Name=Lmbrd1 {ECO:0000313|RefSeq:XP_005086575.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005086575.1};
RN [1] {ECO:0000313|RefSeq:XP_005086575.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC {ECO:0000256|ARBA:ARBA00009901}.
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DR RefSeq; XP_005086575.1; XM_005086518.3.
DR AlphaFoldDB; A0A1U7RG68; -.
DR STRING; 10036.ENSMAUP00000019811; -.
DR GeneID; 101830749; -.
DR KEGG; maua:101830749; -.
DR CTD; 55788; -.
DR eggNOG; ENOG502QQ2T; Eukaryota.
DR OrthoDB; 8533at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0045334; C:clathrin-coated endocytic vesicle; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0035612; F:AP-2 adaptor complex binding; IEA:Ensembl.
DR GO; GO:0032050; F:clathrin heavy chain binding; IEA:Ensembl.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR GO; GO:0005158; F:insulin receptor binding; IEA:Ensembl.
DR GO; GO:0140318; F:protein transporter activity; IEA:Ensembl.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:Ensembl.
DR GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR GO; GO:0038016; P:insulin receptor internalization; IEA:Ensembl.
DR GO; GO:0061462; P:protein localization to lysosome; IEA:Ensembl.
DR InterPro; IPR006876; LMBR1-like_membr_prot.
DR PANTHER; PTHR16130:SF2; LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1; 1.
DR PANTHER; PTHR16130; LYSOSOMAL COBALAMIN TRANSPORTER-RELATED; 1.
DR Pfam; PF04791; LMBR1; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Developmental protein {ECO:0000256|ARBA:ARBA00023218};
KW Gastrulation {ECO:0000256|ARBA:ARBA00023218};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 538 AA; 61272 MW; 87EB5DF863CD3898 CRC64;
MAAATAELVI GWCIFGLLLL AILAFCWIYV RKYQSQRESE VVSTVTAIFS LAVALIASAL
LPVDIFLVSY MKNQNGTFKE WANANVSVQI ENTVLYGYYT LYSVILFCVF FWIPFVYFYY
EEKDDDDTSK CTQVKTALKY TVGFVVICAL LLLIGAFVPL NLPSNKNSTE WEKVKFLFEE
LGSSHGLAAL SFSISSLTLI GMLAAITYTA YGMSALPLNL IKGTRNAAYE RLENTEDIEE
VEQHIQAIRS KSKDGRPLPA RDRRTLKQCE ERLRTLRKRD RHLEFIENSW WTKFCGALRP
LKIIWGIFFI LVALLFVISL FLSNLDKALH SAGIDSGFII FGTNLSNPLN MLLPLLQTVF
PLDYILITII IMYFIFTSMA GIRNIGIWFF WIRLYKIRRG RTRPQALLFL CMILLLIVLH
TSYMIYSLAP QYVMYGSQNY LIESNITSDV HKGNSTLSVP RRCDADAPED QCTVTRTYLF
LHKFWFFSAA YYFGNWAFLG VFLIGLIVSC CKGKKSVIEG VDEDSDISDD DEPSAYSV
//
