ID A0A1U7RGM3_MESAU Unreviewed; 263 AA.
AC A0A1U7RGM3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Rano class II histocompatibility antigen, A beta chain-like {ECO:0000313|RefSeq:XP_005086914.2};
GN Name=LOC101834868 {ECO:0000313|RefSeq:XP_005086914.2};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005086914.2};
RN [1] {ECO:0000313|RefSeq:XP_005086914.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the MHC class II family.
CC {ECO:0000256|ARBA:ARBA00007394}.
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DR RefSeq; XP_005086914.2; XM_005086857.3.
DR AlphaFoldDB; A0A1U7RGM3; -.
DR STRING; 10036.ENSMAUP00000023171; -.
DR GeneID; 101834868; -.
DR KEGG; maua:101834868; -.
DR eggNOG; ENOG502RYBQ; Eukaryota.
DR OrthoDB; 3785866at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR GO; GO:0005771; C:multivesicular body; IEA:Ensembl.
DR GO; GO:0042605; F:peptide antigen binding; IEA:Ensembl.
DR GO; GO:1990405; F:protein antigen binding; IEA:Ensembl.
DR GO; GO:0015643; F:toxic substance binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IEA:Ensembl.
DR GO; GO:0002344; P:B cell affinity maturation; IEA:Ensembl.
DR GO; GO:0071346; P:cellular response to type II interferon; IEA:Ensembl.
DR GO; GO:0046635; P:positive regulation of alpha-beta T cell activation; IEA:Ensembl.
DR GO; GO:0002579; P:positive regulation of antigen processing and presentation; IEA:Ensembl.
DR GO; GO:0002827; P:positive regulation of T-helper 1 type immune response; IEA:Ensembl.
DR CDD; cd21001; IgC1_MHC_II_beta_HLA-DQ_I-A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR000353; MHC_II_b_N.
DR PANTHER; PTHR19944:SF101; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ BETA 1 CHAIN; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00969; MHC_II_beta; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00921; MHC_II_beta; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW MHC II {ECO:0000256|ARBA:ARBA00023182};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..263
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010540978"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 123..211
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 263 AA; 29587 MW; C9352500C7DAD46F CRC64;
MAPQVPSLLL AAAVVLTVLS SPGAQGRDTS RDSVLQYMGL CYYTNGTQRM RSVSKWIYNQ
EEILRFDSDV GEYRAVTELG RPTAESWNSQ KDFLEQRRAD IETVCRHNYG IFDSFIVQRR
EQPRVAVYLT RTEALNHHNL LVCSVTDFYP AQIKVRWFRN GQEETVGVVS TKLIQNGDWT
FQILVMLEMT PQRGDVYTCH VEHPSLQSPV TVEWSAQSES AQSKMLSGIG GFVLGLIFLG
LGLFIHHRSQ KGAHGPPPAG LLQ
//
