ID A0A1U7RH21_ALLSI Unreviewed; 698 AA.
AC A0A1U7RH21;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN Name=LOC102380162 {ECO:0000313|RefSeq:XP_006023311.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006023311.1};
RN [1] {ECO:0000313|RefSeq:XP_006023311.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
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DR RefSeq; XP_006023311.1; XM_006023249.2.
DR AlphaFoldDB; A0A1U7RH21; -.
DR GeneID; 102380162; -.
DR KEGG; asn:102380162; -.
DR eggNOG; KOG0476; Eukaryota.
DR OrthoDB; 1194at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03683; ClC_1_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR002250; Cl_channel-K.
DR PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR PANTHER; PTHR45720:SF3; CHLORIDE CHANNEL PROTEIN CLC-KB; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR PRINTS; PR01119; CLCHANNELKDY.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361221};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 55..76
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 206..229
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 287..311
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 331..350
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 401..424
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 430..453
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 500..517
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 556..616
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 698 AA; 77630 MW; 5B1FB2EB387BD131 CRC64;
MATEGLDRRE HDVAKEEERI LILNEIWRPW PKTRRRVQGC LDCVKRQLFR VGEDWYFLFA
LGVIMAMISF VMDFTINTLL NAHRWLYQEL GDYLVLKYLS WTMYPIALVA FSTGYAQSIT
PHSGGSGIPE LKTILTGVML EDYLAIKNFG AKVVGMTCTL AAGSTIFLGK VGPFVHISSI
MAAYLGKIRT SVIGEYENKS KQNEMLVAGA AVGVSTVFGA PISGVLFSIE VVSSHFAVRD
YWRGFFSATC GAFMFRLLAV FNNDQETIMA PFKTNFKIDF PFDLPEIFFF MILGVICGII
SCAYLFCQRW LLGYIRRNKL TAWLMATDKP VYSALVALLL SSITFPPSLG QFMASRLTMK
EYLSCFFDNQ TWGVLSQNAS LARPLQVDPE NLWMEWWDPN ITIYGSLVIF IVMKFWMLIL
ATTLPMPAGY FMPIFVYGAG IGRLIGEVVA FLFPHGIKLD GAANPIIPGG YALAGAAAFS
GSVTHTISTA LLVFEVTGQI AHILPVILAV LIANAIAQKF QPSFYDGTII VKKLPYLPRI
RSRHIDSYRV TTDQFMNTDF AVLPKGATFE EILQVVTSTD DLEYPIVESA ESLLLVGTVP
RSELVKFLQT HEDAKLSSQE AGEKDKALCS GTLGENCTIN PITFQLSPCT SLHQTHHLFE
LLNLQRVFVT SLGRVIGAVS RSEVKKAIED LANPKTAK
//
