ID A0A1U7RHF5_ALLSI Unreviewed; 3707 AA.
AC A0A1U7RHF5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=CUB and sushi domain-containing protein 3 isoform X1 {ECO:0000313|RefSeq:XP_006018134.1};
GN Name=CSMD3 {ECO:0000313|RefSeq:XP_006018134.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006018134.1};
RN [1] {ECO:0000313|RefSeq:XP_006018134.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR RefSeq; XP_006018134.1; XM_006018072.3.
DR GeneID; 102372702; -.
DR KEGG; asn:102372702; -.
DR CTD; 114788; -.
DR eggNOG; KOG4297; Eukaryota.
DR InParanoid; A0A1U7RHF5; -.
DR OrthoDB; 4195954at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 28.
DR CDD; cd00041; CUB; 14.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 28.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 14.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656:SF4; PROTEIN BETA CHAIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR Pfam; PF00431; CUB; 14.
DR Pfam; PF00084; Sushi; 28.
DR SMART; SM00032; CCP; 28.
DR SMART; SM00042; CUB; 14.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 28.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 14.
DR PROSITE; PS01180; CUB; 14.
DR PROSITE; PS50923; SUSHI; 28.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3631..3652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..173
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 176..237
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 241..345
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 484..545
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 548..659
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 662..719
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 721..829
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 832..893
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 895..1003
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1008..1065
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1067..1177
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1180..1239
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1241..1349
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1352..1412
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1414..1523
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1526..1586
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1588..1696
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1699..1760
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1762..1870
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1876..1937
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1939..2047
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2050..2109
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2111..2219
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2222..2281
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2283..2394
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2393..2454
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2456..2567
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2567..2629
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2630..2691
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2692..2756
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2757..2814
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2815..2872
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2873..2930
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2931..2992
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2993..3050
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3054..3111
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3112..3170
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3171..3230
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3231..3288
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3289..3346
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3350..3408
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3409..3468
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 690..717
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1036..1063
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1414..1441
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 2785..2812
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2843..2870
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2901..2928
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2963..2990
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3021..3048
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3082..3109
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3141..3168
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3259..3286
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3317..3344
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3379..3406
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 3707 AA; 405888 MW; 80DED1791896F54B CRC64;
MQGICKGGIR AKESRLADFW ERGCTKCGRL DFILVKKMGI KSGFTFWNLV FLLLVSCVKG
FIYTCGGTLK GLNGTIESPG FPYGYPNGAN CTWVIIAEER NRIQIVFQSF ALEEEYDYLS
LYDGHPHPTN FRTRLTGFHL PPPVTSTKSV FSLRLTSDFA VSAHGFKVFY EELQSSSCGN
PGVPPKGILY GTRFDVGDKI RYSCVTGYIL DGHPQLTCIA NSVNTASWDF PVPICRAEDA
CGGTMRGSSG IVSSPGFPNE YHNNADCTWT IVAEPGDTIS LIFTDFQMEE KYDYLEIEGS
EPPTIWLSGM NIPPPIISNK NWLRLHFVTD SNHRYRGFSA PYQGSSTLNK TASTGELEER
IATSTGAITV ARTSADVTVS SVTDGTNHRL SEEQRVQATN IRKSILEPTT FNEALSLHQA
DIQSTGRRPR NAEQIERTKE LAVVTHRVKK AIDFKSRGFK LFPGKDNSNK FSILNEGGIK
QASNLCPDPG EPENGKRIGS DFSLGATIQF SCDEDYVLQG SKSITCQRIA EVFAAWSDHR
PVCKVKTCGS NLQGPSGTFT SPNFPFQYDS NAQCVWVVTA INNNKVIQIN FEEFDLEIGY
DTLTIGDGGE VGDPKTVLQV LTGSFVPDLI VSMSSQMWLH LQTDESVGSI GFKVNYKEIE
KESCGDPGTP LYGIREGDGF SNRDVLRFEC QFGFELIGEK SIVCQENNQW SANIPICIFP
CLSNFTAPMG TVLSPDYPEG YGNNLNCIWT IISDPGSRIH LSFNDFDLES QFDFLAVKDG
DSPDSPLLGT FTGAEVPSHL TSNGHILRLE FQADHSMSGR GFNISYNTFG HNECPDPGVP
INARRFGDNF QLGSSISVIC EEGFIKTQGT ETITCILMDG KVMWSGPIPK CGAPCGGHFS
SPSGVILSPG WPGYYKDSLN CEWVIEAEPG HSIKITFERF QTELNYDVLE VHDGPNLLSP
LLGSYNGTQV PQFLFSSSNF IYLLFTTDNS RSNNGFKIHY ESVTVNTYSC LDPGIPVHGR
RYGHDFSIGS TVSFSCDPGY RLSHEEPLLC EKNHWWSHPL PTCDALCGGD VRGPSGTILS
PGYPELYPNS LNCTWTVDVT HGKGVQFTFY TFHLEDHHDY LLITENGSFT QPLARLTGSD
LPSPINAGLY GNFRAQLRFI SDFSISYEGF NISFSEYNLE PCEDPGIPQF GNRIGFNFGV
GDTLTFSCSS GYRLEGASEI ICLGGGRRVW SAPLPRCVAE CGASTTNNEG ILLSPNYPLN
YENNHECIYS IQVQAGKGIN ISARTFHLAQ GDVLKIYDGR DNTAHLLGAF TGASLRGLTL
SSTSNHLWLE FNSDTEGTDE GFQLVYTSFE LSHCEDPGVP QFGYKISDQG HFAGSTIIYG
CNPGYTLHGS SLLKCMTGER RAWDYPLPSC IAECGGRFKG ESSGRILSPG YPFPYDNNLR
CMWMIEVDPG NIVSLQFLAF DTEASHDILR VWDGPPENEM LLKEISGSLI PEGIHSTLNI
VTIQFDTDFY ISKSGFAIQF SSSVATACRD PGVPMNGTRN GDGREPGDTV IFQCDPGYEL
QGDERITCIQ VENRYFWQPN PPVCIAPCGG NLTGSSGFIL SPNFPHPYPH SRDCDWTITV
NNDYVISLAF ISFSIEPNYD FLYIYDGADS NSPLIGSFQD SKLPERIESS SNNMHLAFRS
DGSVSFTGFH LEYKAKLRES CFDPGNIMNG TRLGMDYKLG STVTYYCDAG YVLQGYSTLT
CIMGDDGRPG WNRALPSCHA PCGSRSTGSE GTVLSPNYPK NYSVGHNCVY SIAVPKEFVV
FGQFVFFQTL LHDVVEVYDG PTQQSSLLSS LSGSHSGESL PLSSGNQITV RFTSVGPVTA
KGFHFVYQAV PRTSATQCSS VPEPRFGKRI GNEFAVGSLV LFECNPGYIL HGSIAIRCDT
VPNALAQWND SLPTCIVPCG GILTKRKGTI LSPGYPEPYD NNLNCVWKIT VPEGAGIQVQ
VVSFATEHNW DSLDFYDGAD NNAPRLGSYS GTTIPPLLNS TSNNLYLNFQ SDISVSAAGF
HLEYTAIGLD SCPEPQTPSS GIKIGDRYMV GDVVSFQCDQ GYSLQGHSHI TCMPGPVRRW
NYPIPICLAQ CGGGMSDFSG VILSPGFPGN YPSSLDCTWT IRLPIGFGVH LQFVNFSTET
IHDYLEVRSG STETSTVIGR LSGPQLPSPL FSTTHETSLY FHSDYSQNKQ GFHIIYQAYQ
LQSCPDPRPF RNGFVIGNDF TVGQTISFEC FPGYTLIGNS ALTCLHGISR NWNHPLPRCE
ALCGGNITAM NGTIYSPGYP DEYPNFQDCF WLVRVPPGNG IYINFTVLQT EPIYDFITVW
DGPDQTSPQI GQFSGNTALE SVYSTSNQIL IKFHSDFTTS GFFVLSYHAY QLRVCQPPPS
IPNAEILTED DEFEIGDIIR YQCQPGFTLV GNEILTCRLG ERLQMDGAPP TCQVLCPANE
MRLDSTGIIL SPGYPDSYPN LQMCAWTITV EKGYNISMFF EFFQTEKEFD ILEVFDGPNS
HSPLLISLSG DYSSTLNITS NSHEVFLRWS ADHGTNKKGF RIRYIALYCS TPESPPHGFI
VSQTGGQLNS VVRWACDRGF RLVGKSTAVC RKSPHGYYTW DVPVPACQAI SCGIPKAPVN
GGILTTDYLV GTRVTYFCND GYRLSSKELT TAVCQPDGTW SNHNKTPRCV VVTCPSINSF
TLEHGRWRIV NGSHYEYKTK VVFSCDPGYY GLGPASIECL ANGTWSWRNE RPYCQIISCG
ELPTPPNGNK IGTQITYGST AIFTCDSGYM LVGSAVRECL SSGLWSGTET RCLAGHCGVP
DIIVNGQVIG ENYGYRDTVV YQCNPGFRLI GSSVRICQQD HNWSGQLPSC VPVSCGHPGS
PIYGRTSGNG FNFNDVVTFS CNTGYIMQGP TKAQCQANRQ WSHPPPICKV VNCSDPGIPA
NSIRESKIEH GNFTYGTVVF YDCNPGYFLF GSSVLICQPN GHWDKPLPEC IMIDCGHPGI
PPNMVLSGDK YSFGSTVHYT CTGRRSLVGQ SSRTCQLNGH WSGSLPHCSG DTSGSCGDPG
IPGHGSREDS DFKIKSTVRF SCDIGYILHG SEERTCLANG TWTGRQPECK AVQCGNPGTT
ANGKVFRIDG TTFSNSVIYS CMEGYILSGS SVRQCSANGT WSGSLPNCTI ISCGDPGIPP
NGMRYGDDYV VGQNVTYMCQ PGYIMESNSS IIRTCTSNGT WSGTVPTCKA VTCPTPPQIS
NGRLEGTNFD WGFSISYVCS PGYELSFPAV LTCVGNGTWS GEVPQCLPKF CGDPGIPAQG
KREGKSFIYQ SEVSFSCHIP FILVGSSTRI CQADGSWSGS SPRCIEPTRT ACENPGVPRH
GSQNNTFGYQ VGNVVQFQCK KGHLLHGSTT RTCLPDLTWS GIQPECIPHN CKQPETPSHA
NVAGMDLPSL GYTLIYTCQS GFFLAGGSEH RACRSDGTWT GKVPVCEAGS KILVKDPRPA
LGTPSPKLSV PDDVFAQNYI WKGSYNYKGK KQPMTLTVTS FNASSGRVNA TLTNSNMELL
LSGLYKSQEA RLMLHIYLIK APSHTTVSKM KEEKWAMDGF VSTEPDGATY VFQGFIQGKD
YGQFGLQRLG LNVSEGSNSS NQPHGTNSSS VAIAILVPFF ALIFAGFGFY LYKQRTAPKT
QYTGCSVHEN NNGQAAFENP MYDTNAKSVE GKAVRFDPNL NTVCTMV
//
