ID   A0A1U7RK63_ALLSI        Unreviewed;      1049 AA.
AC   A0A1U7RK63;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Probable E3 ubiquitin-protein ligase HERC4 isoform X4 {ECO:0000313|RefSeq:XP_006024872.1};
GN   Name=HERC4 {ECO:0000313|RefSeq:XP_006024872.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006024872.1};
RN   [1] {ECO:0000313|RefSeq:XP_006024872.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_006024872.1; XM_006024810.3.
DR   AlphaFoldDB; A0A1U7RK63; -.
DR   GeneID; 102369911; -.
DR   KEGG; asn:102369911; -.
DR   CTD; 26091; -.
DR   eggNOG; KOG0941; Eukaryota.
DR   OrthoDB; 5475808at2759; -.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   PANTHER; PTHR45700:SF8; HECT DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF00632; HECT; 1.
DR   Pfam; PF00415; RCC1; 7.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR   PROSITE; PS50237; HECT; 1.
DR   PROSITE; PS00626; RCC1_2; 3.
DR   PROSITE; PS50012; RCC1_3; 7.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   REPEAT          1..52
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          53..102
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          103..155
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          156..208
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          209..260
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          261..312
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          314..381
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   DOMAIN          722..1049
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   ACT_SITE        1017
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   1049 AA;  117800 MW;  C88256AEAC27BAD8 CRC64;
     MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FLNKKVRDVG CGLRHTVFVL DDGTVYTCGC
     NDLGQLGHEK ARKRPEHVGA LDAQNIVSVS CGEAHTLALN DKGQVYAWGL ATEGQLGLPG
     TEECIRVPRN IKSLSEIQIV QVACGYCHSL ALSKGSEVFS WGQNKYGQLG LGYEFKKQTS
     PQLIKSLLGI PFAQIAAGGA HSFVLTLSGA IFGWGRNKFG QLGLNDENDR YVPTLLKSLR
     SQKIVHICCG EDHTAALTKE GGVFTFGAGG YGQLGHNSTS HEINPRKVFE LMGSIVTQIA
     CGRQHTAAFV PSSGRIYSFG LGGNGQLGTG TTSNRKSPFT VKGNWLSYSE ASNPPTTDNE
     QYYCVKRIFS GGDQSFAHYF NPQNMVLPDD FRYPDSSKQI WNVNEAFIQR LLTCSSGRLP
     VEIANEIDGT FSSAGCLNGS FLAVSNDDHY RTSTRFSGVD MNAARLLFHK LIQPDHPHIS
     QQVAASLEKN LIPKLTSSLP DVEALRLYLT LPECPLMSDV NNFTTLALPF GAAVINLEKA
     PLKVLENWWS VLEPPLFLKI VELYKDVVVH LLKLYKIGIP TSERRIFSSF LHTAFKVLEI
     LHKVNERGQI IQYDKFYIHE IEDLIDIRND YINWVQHQAY GMLAEIPVTI CTYPFVFDAQ
     AKTTLLQTDA VLQMQMAVDQ AHRQNFSSLF LPVYESVNPC LILMVRRDNI VGDAVEVLRK
     TKNLDYKKPL KVIFVGEEAV DAGGVRKEFF LLIMRELLDP KYGMFRYYEE SRLIWFSDKT
     FEDSDLFHLI GVVCGLAIYN FTIIDLHFPL ALYKKLLNKK PSLDDLKELM PDVGRSMQQL
     LDYPEDDIEE TFCLNFTITV ENFGTTEIKE LVPNGADIPV VKQNRQEFVD SYVDYIFNKS
     VASLFNAFHS GFHKVCGGKV LQLFQPSELQ AMVIGNTNYD WKELEKNTEY KGEYWADHPT
     VKLFWEVFHE LSLEKKKQFL LFLTGSDRIP ILGMKCLKLV IQPTGGGEEY LPVAHTCFNL
     LDLPKYTDKE ILKSKLIQAI DHYEGFSLV
//