UniProt: A0A1U7RL56

Database: UniProt
Entry: A0A1U7RL56_ALLSI

LinkDB:  A0A1U7RL56_ALLSI 
Original site:  A0A1U7RL56_ALLSI

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Ontology (5)   
   GO (5)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (13)   
   InterPro (6)   
   Pfam (2)   
   PROSITE (3)   
   SMART (2)   
All databases (21)   

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ID   A0A1U7RL56_ALLSI        Unreviewed;       438 AA.
AC   A0A1U7RL56;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Oxysterols receptor LXR-beta isoform X1 {ECO:0000313|RefSeq:XP_006014951.1};
GN   Name=NR1H2 {ECO:0000313|RefSeq:XP_006014951.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006014951.1};
RN   [1] {ECO:0000313|RefSeq:XP_006014951.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000256|RuleBase:RU004334}.
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DR   RefSeq; XP_006014951.1; XM_006014889.3.
DR   AlphaFoldDB; A0A1U7RL56; -.
DR   STRING; 38654.A0A1U7RL56; -.
DR   GeneID; 102386463; -.
DR   KEGG; asn:102386463; -.
DR   CTD; 7376; -.
DR   eggNOG; KOG3575; Eukaryota.
DR   InParanoid; A0A1U7RL56; -.
DR   OrthoDB; 5390715at2759; -.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   CDD; cd07160; NR_DBD_LXR; 1.
DR   CDD; cd06954; NR_LBD_LXR; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR023257; Liver_X_rcpt.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR   PANTHER; PTHR24082:SF316; OXYSTEROLS RECEPTOR LXR-BETA; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR02034; LIVERXRECPTR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004334};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU004334};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU004334};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT   DOMAIN          78..153
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   DOMAIN          200..438
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51843"
FT   REGION          1..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          160..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          219..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   438 AA;  49577 MW;  6AC0D73E75B1B65F CRC64;
     MATPGSDLLP ENREPWSPAP TRAPDPELKN EGPHSQLELG AVPDSEVPGT DGEGTAQSTG
     EEPVRRHRKG PAPKMLGTER CSVCGDKASG FHYNVLSCEG CKGFFRRSVI KGAQYACRGA
     GQCHMDPYMR RKCQLCRLRK CRQAGMREQY VLSEEQLRKK KLSRQQQQQE GCGGGEMPRV
     PPLLPDPVLG LPEPAQLTQQ QERMIQQLVA VQQQCNKRSF SDQPKVTPWP LGSDPSSREA
     RQQRFAHFTE LAIISVQEIV DFAKQVPGFL QLAREDQIAL LKASTIEIML LETARRYNHE
     TESITFLKDF TYSKDDFHRA GLQVEFINPI FEFSRGMRGL QLDDAEYALL IAIDLFSGDR
     PGVQHRAQVE ALQLPYVEAL HAYTRIQRPQ DRLMFPRMLL KLVALRTLSS VHSEQVFALR
     LQDKKLPPLL SEIWDVHE
//

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